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Review
. 2019 Dec;35(12):1034-1042.
doi: 10.1051/medsci/2019227. Epub 2020 Jan 6.

[Antibody-drug conjugates in oncology. Recent success of an ancient concept]

[Article in French]
Alain Beck  1 , Charles Dumontet  2 , Nicolas Joubert  3
Affiliations
Free article
Review

[Antibody-drug conjugates in oncology. Recent success of an ancient concept]

[Article in French]
Alain Beck et al. Med Sci (Paris). 2019 Dec.
Free article

Abstract
in English, French

An Antibody-Drug Conjugate (armed antibody) is a vectorized chemotherapy that results from the grafting of a cytotoxic agent on a monoclonal antibody thanks to a judiciously designed spacer arm. ADCs have made considerable progress in 10 years. In 2009, only gemtuzumab ozogamicin (Mylotarg®) was used clinically. In 2019, 4 other ADCs have been approved and more than 80 others are in active clinical trials. The first part of this review will focus on Food and Drug Administration-approved Antibody-Drug Conjugates, their limitations as well as their associated toxicity and resistance mechanisms.

Title: Les immuno-conjugués en oncologie - Les raisons du succès récent d’une approche ancienne.

Abstract: Un anticorps armé (antibody-drug conjugate en anglais) est une chimiothérapie vectorisée qui résulte du greffage d’un agent cytotoxique sur un anticorps monoclonal par l’intermédiaire d’un bras espaceur judicieusement construit. Les anticorps armés ont fait des progrès considérables en 10 ans. En 2009, seul le gemtuzumab ozogamicine (Mylotarg®) était utilisé en clinique. En 2019, 4 autres ADC ont été approuvés par la Food and drug administration et plus de 80 autres sont en études cliniques actives. La première partie de cette revue sera focalisée sur les anticorps armés approuvés, leurs limitations, ainsi que leur toxicité et mécanismes de résistances associés.

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References

    1. Joubert N, Denevault-Sabourin C, Bryden F, et al. Towards antibody-drug conjugates and prodrug strategies with extracellular stimuli-responsive drug delivery in the tumor microenvironment for cancer therapy. Eur J Med Chem 2017 ; 142: 393–415.
    1. Beck A, Terral G, Debaene F, et al. Cutting-edge mass spectrometry methods for the multi-level structural characterization of antibody-drug conjugates. Expert Rev Proteomics 2016 ; 13: 157–183.
    1. Haeuw JF, Caussanel V, Beck A. Les immunoconjugués, anticorps « armés » pour combattre le cancer. Med/Sci (Paris) 2009 ; 25: 1046–1052.
    1. Beck A, Goetsch L, Dumontet C, et al. Strategies and challenges for the next generation of antibody–drug conjugates. Nat Rev Drug Discov 2017 ; 16: 315–337.
    1. Martin C, Kizlik-Masson C, Pèlegrin A, et al. Antibody-drug conjugates: design and development for therapy and imaging in and beyond cancer, labEx MAbImprove industrial workshop, July 27–28, 2017, Tours. France. MAbs 2017 ; 10: 210–221.

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