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Review
. 2020 Mar;83(3):221-226.
doi: 10.1097/JCMA.0000000000000251.

The roles of m6A RNA modifiers in human cancer

Yanwen Liang  1 , Guankai Zhan  2 , Kao-Jung Chang  3   4 , Yi-Ping Yang  3   4 , Lingfang Wang  2 , Jiebo Lin  2 , Chih-Hung Hsu  2
Affiliations
Review

The roles of m6A RNA modifiers in human cancer

Yanwen Liang et al. J Chin Med Assoc. 2020 Mar.

Abstract

Like DNA and proteins, RNA is subject to numerous (over 160) covalent modifications which play critical roles to regulate RNA metabolism. Among these modifications, N-methyladenosine (mA) is the most prevalent RNA methylation on mRNA which occurs on around 25% of transcripts. The recent studies demonstrated that mA participates in many aspects of RNA processing, including splicing, nuclear exporting, translation, stabilization, etc. Therefore, it revealed a new layer of regulatory mechanism for gene expression and has been termed "RNA Epigenetics" or "Epitranscriptomics". RNA mA is regulated and exerts its functions by three groups of "mA RNA modifiers" including mA methyltransferases (writers), mA demethylases (erasers), and mA binding proteins (readers). In this review, we would summarize and discuss the current understandings of the roles of the conventional mA RNA modifiers in human cancers.

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References

    1. Cohn WE, Volkin E. Nucleoside-5′-Phosphates from Ribonucleic Acid.Nature1951167483–4
    1. Machnicka MA, Milanowska K, Osman Oglou O, Purta E, Kurkowska M, Olchowik A, et al. MODOMICS: a database of RNA modification pathways–2013 update.Nucleic Acids Res201341D262–7
    1. Wei CM, Gershowitz A, Moss B. Methylated nucleotides block 5’ terminus of hela cell messenger RNA.Cell19754379–86
    1. Wei CM, Gershowitz A, Moss B. 5’-terminal and internal methylated nucleotide sequences in hela cell mrna.Biochemistry197615397–401
    1. Dominissini D, Moshitch-Moshkovitz S, Schwartz S, Salmon-Divon M, Ungar L. Topology of the human and mouse m6A RNA methylomes revealed by m6A-seq.Nature2012485201–6

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