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Review
. 2019 Dec 28;9(1):30.
doi: 10.3390/antiox9010030.

Exposure to Toxic Heavy Metals Can Influence Homocysteine Metabolism?

Caterina Ledda  1 , Emanuele Cannizzaro  2 , Piero Lovreglio  3 , Ermanno Vitale  1 , Angela Stufano  3 , Angelo Montana  4 , Giovanni Li Volti  5 , Venerando Rapisarda  1
Affiliations
Review

Exposure to Toxic Heavy Metals Can Influence Homocysteine Metabolism?

Caterina Ledda et al. Antioxidants (Basel). .

Abstract

Background: Homocysteine is a sulfur amino acid whose metabolism is activated in two pathways: remethylation to methionine, which requires folate and vitamin B12, and transsulfuration to cystathionine, which needs pyridoxal-5'-phosphate. High homocysteine level increases the risk of developing heart disease, stroke, peripheral vascular diseases, and cognitive impairment. Some evidence showed that exposure to these metals increased plasma homocysteine levels.

Methods: A systematic review was carried out to clarify the relationship between homocysteine blood levels and exposure to toxic heavy metals (Lead, Cadmium, Mercury, and Chromium).

Results: The results of this systematic review indicate that exposure to Pb, Cr, Cd, and Hg is connected with nonphysiological homocysteine levels or vitamin B12 and folate serum concentrations.

Conclusions: These findings reinforce the importance of involvement in exposure to heavy metals in homocysteine metabolism. This supports the role of blood metals as potential upstream modifiable risk factors to prevent the development of other established risk factors as hyperhomocysteinemia.

Keywords: MTHFR; cadmium; chromium; folate; lead; mercury; methionine; vitamin B12; vitamin B6.

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Conflict of interest statement

The authors declare no conflicts of interest.

Figures

Figure 1
Figure 1
Flow diagram illustrating included and excluded studies in this systematic review.
Figure 2
Figure 2
Graphical map of the geographical distribution of selected studies.
See this image and copyright information in PMC

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