Editorial

. 2019 Dec 30;12(1):90.

doi: 10.3390/cancers12010090.

Metabolic Reprogramming and Vulnerabilities in Cancer

Costas A Lyssiotis^{1

2

3}, Deepak Nagrath^{4

5

6}

Affiliations

¹ Department of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, MI 48109, USA.
² Division of Gastroenterology and Hepatology, Department of Internal Medicine, University of Michigan, Ann Arbor, MI 48109, USA.
³ Rogel Cancer Center, University of Michigan, Ann Arbor, MI 48109, USA.
⁴ Department of Biomedical Engineering, University of Michigan, Ann Arbor, MI 48109, USA.
⁵ Department of Chemical Engineering, University of Michigan, Ann Arbor, MI 48109, USA.
⁶ Biointerfaces Institute, University of Michigan, Ann Arbor, MI 48109, USA.

PMID: 31905922
PMCID: PMC7016671
DOI: 10.3390/cancers12010090

Editorial

Metabolic Reprogramming and Vulnerabilities in Cancer

Costas A Lyssiotis et al. Cancers (Basel). 2019.

. 2019 Dec 30;12(1):90.

doi: 10.3390/cancers12010090.

Authors

Costas A Lyssiotis^{1

2

3}, Deepak Nagrath^{4

5

6}

Affiliations

¹ Department of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, MI 48109, USA.
² Division of Gastroenterology and Hepatology, Department of Internal Medicine, University of Michigan, Ann Arbor, MI 48109, USA.
³ Rogel Cancer Center, University of Michigan, Ann Arbor, MI 48109, USA.
⁴ Department of Biomedical Engineering, University of Michigan, Ann Arbor, MI 48109, USA.
⁵ Department of Chemical Engineering, University of Michigan, Ann Arbor, MI 48109, USA.
⁶ Biointerfaces Institute, University of Michigan, Ann Arbor, MI 48109, USA.

PMID: 31905922
PMCID: PMC7016671
DOI: 10.3390/cancers12010090

Abstract

Metabolic programs are rewired in tumors to support growth, progression, and immune evasion. A wealth of work in the past decade has delineated how these metabolic rearrangements are facilitated by signaling pathways downstream of oncogene activation and tumor suppressor loss. More recently, this field has expanded to include metabolic interactions among the diverse cell types that exist within a tumor and how this impacts the immune system. In this special issue, 17 review articles discuss these phenomena, and, alongside four original research manuscripts, the vulnerabilities associated with deregulated metabolic programming are highlighted and examined.

Keywords: amino acids; cancer associated fibroblasts; cancer metabolism; carbohydrates; iron; lipids; nucleotides; reactive oxygen species; redox; tumor microenvironment.

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Conflict of interest statement

The authors declare no conflicts of interest.

Figures

**Figure 1**
Schematic overview of the themes in the Special Issue on Metabolic Reprogramming and Vulnerabilities in Cancer. A.O: Antioxidants. Figure design by Heather Giza.

See this image and copyright information in PMC

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References

1. Hanahan D., Weinberg R.A. Hallmarks of cancer: The next generation. Cell. 2011;144:646–674. doi: 10.1016/j.cell.2011.02.013. - DOI - PubMed
1. Yan L., Raj P., Yao W., Ying H. Glucose Metabolism in Pancreatic Cancer. Cancers. 2019;11:1460. doi: 10.3390/cancers11101460. - DOI - PMC - PubMed
1. Villa E., Ali E.S., Sahu U., Ben-Sahra I. Cancer Cells Tune the Signaling Pathways to Empower de Novo Synthesis of Nucleotides. Cancers. 2019;11:688. doi: 10.3390/cancers11050688. - DOI - PMC - PubMed
1. Choi B.-H., Coloff J.L. The Diverse Functions of Non-Essential Amino Acids in Cancer. Cancers. 2019;11:675. doi: 10.3390/cancers11050675. - DOI - PMC - PubMed
1. Bott A.J., Maimouni S., Zong W.-X. The Pleiotropic Effects of Glutamine Metabolism in Cancer. Cancers. 2019;11:770. doi: 10.3390/cancers11060770. - DOI - PMC - PubMed

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Metabolic Reprogramming and Vulnerabilities in Cancer

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Metabolic Reprogramming and Vulnerabilities in Cancer

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Conflict of interest statement

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