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Review
. 2019 Dec 30;9(1):94.
doi: 10.3390/jcm9010094.

Ulcerative Colitis: Current and Emerging Treatment Strategies

Maia Kayal  1 , Shailja Shah  2
Affiliations
Review

Ulcerative Colitis: Current and Emerging Treatment Strategies

Maia Kayal et al. J Clin Med. .

Abstract

Historically, medical therapy for ulcerative colitis (UC) was limited to corticosteroids. Excitingly, over the past just 1-2 decades, the options for medical therapy have expanded and include biologics and small molecules, with more agents actively being developed. In this article, we review the current and emerging treatment strategies for UC stratified according to disease severity.

Keywords: biologic; colectomy; small molecule; ulcerative colitis.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Ulcerative colitis disease extent.
See this image and copyright information in PMC

References

    1. Abraham C., Cho J.H. Inflammatory bowel disease. N. Engl. J. Med. 2009;361:2066–2078. doi: 10.1056/NEJMra0804647. - DOI - PMC - PubMed
    1. Silverberg M.S., Satsangi J., Ahmad T., Arnott I.D., Bernstein C.N., Brant S.R., Caprilli R., Colombel J.-F., Gasche C., Geboes K., et al. Toward an integrated clinical, molecular and serological classification of inflammatory bowel disease: Report of a Working Party of the 2005 Montreal World Congress of Gastroenterology. Can. J. Gastroenterol. 2005;19(Suppl. A):5a–36a. doi: 10.1155/2005/269076. - DOI - PubMed
    1. Ungaro R., Mehandru S., Allen P.B., Peyrin-Biroulet L., Colombel J.F. Ulcerative colitis. Lancet. 2017;389:1756–1770. doi: 10.1016/S0140-6736(16)32126-2. - DOI - PMC - PubMed
    1. Cosnes J., Gower-Rousseau C., Seksik P., Cortot A. Epidemiology and natural history of inflammatory bowel diseases. Gastroenterology. 2011;140:1785–1794. doi: 10.1053/j.gastro.2011.01.055. - DOI - PubMed
    1. Cohen R.D., Yu A.P., Wu E.Q., Xie J., Mulani P.M., Chao J. Systematic review: The costs of ulcerative colitis in Western countries. Aliment. Pharmacol. Ther. 2010;31:693–707. doi: 10.1111/j.1365-2036.2010.04234.x. - DOI - PubMed

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