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Review
. 2020 Jan;22(1):7-17.
doi: 10.1038/s41556-019-0444-9. Epub 2020 Jan 6.

Dynamic responses of the haematopoietic stem cell niche to diverse stresses

Antoniana Batsivari #  1 , Myriam Luydmila Rachelle Haltalli #  2   3 , Diana Passaro #  1 , Constandina Pospori #  1   2   3 , Cristina Lo Celso  4   5   6 , Dominique Bonnet  7
Affiliations
Review

Dynamic responses of the haematopoietic stem cell niche to diverse stresses

Antoniana Batsivari et al. Nat Cell Biol. 2020 Jan.

Erratum in

Abstract

Adult haematopoietic stem cells (HSCs) mainly reside in the bone marrow, where stromal and haematopoietic cells regulate their function. The steady state HSC niche has been extensively studied. In this Review, we focus on how bone marrow microenvironment components respond to different insults including inflammation, malignant haematopoiesis and chemotherapy. We highlight common and unique patterns among multiple cell types and their environment and discuss current limitations in our understanding of this complex and dynamic tissue.

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