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Comment
. 2020 Mar;11(3):158-160.
doi: 10.1007/s13238-019-00677-7.

Atomic-resolution view of complete TCR-CD3 revealed

Jijie Chai  1
Affiliations
Comment

Atomic-resolution view of complete TCR-CD3 revealed

Jijie Chai. Protein Cell. 2020 Mar.
No abstract available

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Figures

Figure 1
Figure 1
cryo-EM structure of the TCR-CD3 complex at 3.7 Å. (A) Overall structure of the TCR-CD3 complex. (B) Structure comparison between TCR-CD3 and OKT3-bound CDεγ. The extracellular domains of CDεγ from the TCR-CD3 complex were used as the template for the structural alignment. The TCR-CD3 structure is shown in the same orientation as that in (A). (C) Structure comparison between TCR-CD3 and pMHC-bound TCR αβ. The extracellular domains of TCR αβ from the TCR-CD3 complex were used as the template for the structural alignment. The antigen peptide is shown red
See this image and copyright information in PMC

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References

    1. Baker BM, Gagnon SJ, Biddison WE, Wiley DC. Conversion of a T cell antagonist into an agonist by repairing a defect in the TCR/peptide/MHC interface implications for TCR signaling. Immunity. 2000;13:475–484. doi: 10.1016/S1074-7613(00)00047-9. - DOI - PubMed
    1. Call ME, Pyrdol J, Wiedmann M, Wucherpfennig KW. The organizing principle in the formation of the T cell receptor-CD3 complex. Cell. 2002;111:967–979. doi: 10.1016/S0092-8674(02)01194-7. - DOI - PMC - PubMed
    1. Dong D, Zheng L, Lin J, Zhang B, Zhu Y, Li N, Xie S, Wang Y, Gao N, Huang Z. Structural basis of assembly of the human TCR–CD3 complex. Nature. 2019 doi: 10.1038/s41586-019-1537-0. - DOI - PubMed
    1. Horejsi V. Lipid rafts and their roles in T-cell activation. Microbes Infect. 2005;7:310–316. doi: 10.1016/j.micinf.2004.12.004. - DOI - PubMed
    1. Krshnan L, Park S, Im W, Call MJ, Call ME. A conserved alpha beta transmembrane interface forms the core of a compact T-cell receptor-CD3 structure within the membrane. Proc Natl Acad Sci USA. 2016;113(43):E6649–E6658. doi: 10.1073/pnas.1611445113. - DOI - PMC - PubMed

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