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Case Reports
. 2019 Dec 27;9(4):2045894019896682.
doi: 10.1177/2045894019896682. eCollection 2019 Oct-Dec.

"Anagrelide-induced pulmonary arterial hypertension": a rare case of drug-induced pulmonary arterial hypertension

Keiko Sumimoto  1 , Yu Taniguchi  1 , Yoichiro Matsuoka  1 , Hiroyuki Onishi  1 , Noriaki Emoto  1 , Ken-Ichi Hirata  1
Affiliations
Case Reports

"Anagrelide-induced pulmonary arterial hypertension": a rare case of drug-induced pulmonary arterial hypertension

Keiko Sumimoto et al. Pulm Circ. .

Abstract

Pulmonary arterial hypertension can be associated with exposure to certain drugs or toxins. However, only a few cases of drug-induced pulmonary arterial hypertension have been previously reported. Anagrelide is an oral imidazoquinazoline agent that is prescribed for reducing elevated platelet counts in patients with myeloproliferative disorders. We report the case of a 70-year-old female patient who developed pulmonary arterial hypertension after taking anagrelide for the treatment of polycythemia vera. Pulmonary arterial hypertension promptly improved after the discontinuation of anagrelide. Anagrelide-induced pulmonary arterial hypertension is a very rare disease, and our case shows that it might be reversible.

Keywords: anagrelide; drug-induced pulmonary arterial hypertension; polycythemia vera.

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Figures

Fig. 1.
Fig. 1.
Transthoracic echocardiography at the first visit. (a) Right atrial and ventricular dilatation. (b) Left ventricle is compressed by right ventricle. (c) Tricuspid regurgitation is severe. (d) Trans-tricuspid pressure gradient is 45 mmHg.
See this image and copyright information in PMC

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