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Review
. 2019 Nov 11:20:14-24.
doi: 10.1016/j.jot.2019.10.006. eCollection 2020 Jan.

Clinical Neurorestorative Therapeutic Guidelines for Spinal Cord Injury (IANR/CANR version 2019)

Hongyun Huang  1   2 , Wise Young  3 , Stephen Skaper  4 , Lin Chen  5 , Gustavo Moviglia  6 , Hooshang Saberi  7 , Ziad Al-Zoubi  8 , Hari Shanker Sharma  9 , Dafin Muresanu  10 , Alok Sharma  11 , Wagih El Masry  12 , Shiqing Feng  13 ; International Association of Neurorestoratology and The Chinese Association of Neurorestoratology
Affiliations
Review

Clinical Neurorestorative Therapeutic Guidelines for Spinal Cord Injury (IANR/CANR version 2019)

Hongyun Huang et al. J Orthop Translat. .

Abstract

Functional restoration after spinal cord injury (SCI) is one of the most challenging tasks in neurological clinical practice. With a view to exploring effective neurorestorative methods in the acute, subacute, and chronic phases of SCI, "Clinical Therapeutic Guidelines of Neurorestoration for Spinal Cord Injury (China Version 2016)" was first ​proposed in 2016 by the Chinese Association of Neurorestoratology (CANR). Given the rapid advances in this field in recent years, the International Association of Neurorestoratology (IANR) and CANR formed and approved the "Clinical Neurorestorative Therapeutic Guidelines for Spinal Cord Injury (IANR/CANR version 2019)". These guidelines mainly introduce restoring damaged neurological structure and functions by varying neurorestorative strategies in acute, subacute, and chronic phases of SCI. These guidelines can provide a neurorestorative therapeutic standard or reference for clinicians and researchers in clinical practice to maximally restore functions of patients with SCI and improve their quality of life.

The translational potential of this article: This guideline provided comprehensive management strategies for SCI, which contains the evaluation and diagnosis, pre-hospital first aid, treatments, rehabilitation training, and complications management. Nowadays, amounts of neurorestorative strategies have been demonstrated to be benefit in promoting the functional recovery and improving the quality of life for SCI patients by clinical trials. Also, the positive results of preclinical research provided lots of new neurorestorative strategies for SCI treatment. These promising neurorestorative strategies are worthy of translation in the future and can promote the advancement of SCI treatments.

Keywords: Cell therapy; Clinical therapeutic guideline; Neurorehabilitation; Neurorestoration; Neurotization; Spinal cord injury.

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Figures

Figure 1
Figure 1
Clinical neurorestorative therapeutic guidelines in the acute and subacute phases of SCI. SCI = spinal cord injury.
Figure 2
Figure 2
American Spinal Injury Association (ASIA) neurological scores.
Figure 3
Figure 3
Neurorestorative therapeutic strategies in acute and subacute phases of SCI. SCI = spinal cord injury.
Figure 4
Figure 4
Injury type and decompression procedure in acute and subacute phases of SCI. SCI = spinal cord injury.
Figure 5
Figure 5
Clinical neurorestorative therapeutic guidelines for chronic phase of SCI. SCI = spinal cord injury.
See this image and copyright information in PMC

References

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