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Case Reports
. 2019 Dec 30;6(1):69-71.
doi: 10.1016/j.jdcr.2019.10.016. eCollection 2020 Jan.

Treatment of granuloma annulare with tofacitinib 2% ointment

William Damsky  1 , Brett A King  1
Affiliations
Case Reports

Treatment of granuloma annulare with tofacitinib 2% ointment

William Damsky et al. JAAD Case Rep. .
No abstract available

Keywords: GA, Granuloma annulare; IFN, interferon; JAK; JAK, Janus kinase; JAK-STAT, Janus kinase signal transducer and activator of transcription; Janus kinase; granuloma annulare; tofacitinib.

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Figures

Fig 1
Fig 1
Effect of tofacitinib 2% ointment in GA. Upper panels, Clinical images before tofacitinib (left panels) and after 15 weeks of tofacitinib 2% ointment twice daily (right panels). Lower panels, a single lesion was left untreated to control for spontaneous resolution of GA. Clinical image of the untreated lesion before and after treatment of the other lesions.
Fig 2
Fig 2
Skin biopsy shows GA. Histocytes and lymphocytes in the dermis, with focal areas of degenerated collagen palisaded by histiocytes, consistent with GA. (Original magnification: ×200.)
See this image and copyright information in PMC

References

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    1. Damsky W., Thakral D., Emeagwali N., Galan A., King B. Tofacitinib treatment and molecular analysis of cutaneous sarcoidosis. N Engl J Med. 2018;379:2540–2546. - PMC - PubMed
    1. Damsky W., Thakral D., McGeary M.K., Leventhal J., Galan A., King B. Janus kinase inhibition induces disease remission in cutaneous sarcoidosis and granuloma annulare. J Am Acad Dermatol. 2019 - PMC - PubMed
    1. Wei J.J., Kallenbach L.R., Kreider M., Leung T.H., Rosenbach M. Resolution of cutaneous sarcoidosis after Janus kinase inhibitor therapy for concomitant polycythemia vera. JAAD Case Rep. 2019;5:360–361. - PMC - PubMed

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