Prevention of CAR-T-cell dysfunction

Martin W LaFleur^{1

2

3}, Brian C Miller^{1

2

3

4}, Arlene H Sharpe^{5

6

7}

Affiliations

¹ Department of Immunology, Blavatnik Institute, Harvard Medical School, Boston, MA, USA.
² Evergrande Center for Immunological Diseases, Harvard Medical School and Brigham and Women's Hospital, Boston, MA, USA.
³ Broad Institute of Harvard and Massachusetts Institute of Technology, Cambridge, MA, USA.
⁴ Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.
⁵ Department of Immunology, Blavatnik Institute, Harvard Medical School, Boston, MA, USA. arlene_sharpe@hms.harvard.edu.
⁶ Evergrande Center for Immunological Diseases, Harvard Medical School and Brigham and Women's Hospital, Boston, MA, USA. arlene_sharpe@hms.harvard.edu.
⁷ Broad Institute of Harvard and Massachusetts Institute of Technology, Cambridge, MA, USA. arlene_sharpe@hms.harvard.edu.

Comment

Martin W LaFleur et al. Nat Biomed Eng. 2020 Jan.

. 2020 Jan;4(1):16-17.

doi: 10.1038/s41551-019-0512-2.

Martin W LaFleur^{1

2

3}, Brian C Miller^{1

2

3

4}, Arlene H Sharpe^{5

6

7}

¹ Department of Immunology, Blavatnik Institute, Harvard Medical School, Boston, MA, USA.
² Evergrande Center for Immunological Diseases, Harvard Medical School and Brigham and Women's Hospital, Boston, MA, USA.
³ Broad Institute of Harvard and Massachusetts Institute of Technology, Cambridge, MA, USA.
⁴ Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.
⁵ Department of Immunology, Blavatnik Institute, Harvard Medical School, Boston, MA, USA. arlene_sharpe@hms.harvard.edu.
⁶ Evergrande Center for Immunological Diseases, Harvard Medical School and Brigham and Women's Hospital, Boston, MA, USA. arlene_sharpe@hms.harvard.edu.
⁷ Broad Institute of Harvard and Massachusetts Institute of Technology, Cambridge, MA, USA. arlene_sharpe@hms.harvard.edu.

No abstract available

Comment on

c-Jun overexpression in CAR T cells induces exhaustion resistance.
Lynn RC, Weber EW, Sotillo E, Gennert D, Xu P, Good Z, Anbunathan H, Lattin J, Jones R, Tieu V, Nagaraja S, Granja J, de Bourcy CFA, Majzner R, Satpathy AT, Quake SR, Monje M, Chang HY, Mackall CL. Lynn RC, et al. Nature. 2019 Dec;576(7786):293-300. doi: 10.1038/s41586-019-1805-z. Epub 2019 Dec 4. Nature. 2019. PMID: 31802004 Free PMC article.

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