Utility of the global CDR^® plus NACC FTLD rating and development of scoring rules: Data from the ARTFL/LEFFTDS Consortium

Toji Miyagawa¹, Danielle Brushaber¹, Jeremy Syrjanen¹, Walter Kremers¹, Julie Fields¹, Leah K Forsberg¹, Hilary W Heuer², David Knopman¹, John Kornak², Adam Boxer², Howard J Rosen², Bradley F Boeve¹, Brian Appleby³, Yvette Bordelon⁴, Jessica Bove⁵, Patrick Brannelly⁶, Christina Caso⁷, Giovanni Coppola⁴, Reilly Dever², Christina Dheel¹, Bradford Dickerson⁸, Susan Dickinson⁹, Sophia Dominguez⁵, Kimiko Domoto-Reilly⁷, Kelley Faber¹⁰, Jessica Ferrell¹¹, Ann Fishman¹², Jamie Fong², Tatiana Foroud¹⁰, Ralitza Gavrilova¹, Debra Gearhart¹, Behnaz Ghazanfari¹³, Nupur Ghoshal¹⁴, Jill S Goldman¹⁵, Jonathan Graff-Radford¹, Neill Graff-Radford¹⁶, Ian Grant¹⁷, Murray Grossman⁵, Dana Haley¹⁶, Robin Hsiung¹⁸, Edward Huey¹⁵, David Irwin⁵, David Jones¹, Lynne Jones¹⁴, Kejal Kantarci¹, Anna Karydas², Daniel Kaufer¹¹, Diana Kerwin¹⁹, Ruth Kraft¹, Joel Kramer², Walter Kukull²⁰, Irene Litvan²¹, Diane Lucente⁸, Codrin Lungu²², Ian Mackenzie¹⁸, Miranda Maldonado⁴, Masood Manoochehri¹⁵, Scott McGinnis⁸, Emily McKinley²³, Mario F Mendez⁴, Bruce Miller², Namita Multani¹³, Chiadi Onyike¹², Jaya Padmanabhan⁸, Alexander Pantelyat¹², Rodney Pearlman²⁴, Leonard Petrucelli¹⁶, Madeline Potter¹⁰, Rosa Rademakers¹⁶, Eliana M Ramos⁴, Kate Rankin², Katya Rascovsky⁵, Erik D Roberson²³, Emily Rogalski¹⁷, Pheth Sengdy¹⁸, Leslie Shaw⁵, Maria C Tartaglia¹⁰, Nadine Tatton⁹, Joanne Taylor², Arthur Toga²⁵, John Q Trojanowski⁵, Ping Wang², Sandra Weintraub¹⁷, Bonnie Wong⁸, Zbigniew Wszolek¹⁶

Affiliations

¹ Mayo Clinic, Rochester, Minnesota, USA.
² University of California San Francisco, San Francisco, California, USA.
³ Case Western Reserve University, Cleveland, Ohio, USA.
⁴ University of California Los Angeles, Los Angeles, California, USA.
⁵ University of Pennsylvania, Philadelphia, Pennsylvania, USA.
⁶ Tau Consortium, Rainwater Charitable Foundation, Fort Worth, Texas, USA.
⁷ University of Washington, Seattle, Washington, USA.
⁸ Harvard University/Massachusetts General Hospital, Boston, Massachusetts, USA.
⁹ Association for Frontotemporal Degeneration, Radnor, Pennsylvania, USA.
¹⁰ National Centralized Repository for Alzheimer's Disease and Related Dementias (NCRAD), Indiana University, Indianapolis, Indiana, USA.
¹¹ University of North Carolina, Chapel Hill, North Carolina, USA.
¹² Johns Hopkins University, Baltimore, Maryland, USA.
¹³ University of Toronto, Toronto, Ontario, Canada.
¹⁴ Washington University, St. Louis, Missouri, USA.
¹⁵ Columbia University, New York, New York, USA.
¹⁶ Mayo Clinic, Jacksonville, Florida, USA.
¹⁷ Northwestern University, Chicago, Illinois, USA.
¹⁸ University of British Columbia, Vancouver, British Columbia, Canada.
¹⁹ University of Texas Southwestern, Dallas, Texas, USA.
²⁰ National Alzheimer Coordinating Center (NACC), University of Washington, Seattle, Washington, USA.
²¹ University of California San Diego, San Diego, California, USA.
²² National Institute of Neurological Disorders and Stroke (NINDS), Bethesda, Maryland, USA.
²³ University of Alabama, Birmingham, Alabama, USA.
²⁴ Bluefield Project, San Francisco, California, USA.
²⁵ Laboratory of Neuroimaging (LONI), University of Southern California, Los Angeles, California, USA.

PMID: 31914218
PMCID: PMC7202045
DOI: 10.1002/alz.12033

Utility of the global CDR^® plus NACC FTLD rating and development of scoring rules: Data from the ARTFL/LEFFTDS Consortium

Toji Miyagawa et al. Alzheimers Dement. 2020 Jan.

. 2020 Jan;16(1):106-117.

doi: 10.1002/alz.12033.

Authors

Affiliations

¹ Mayo Clinic, Rochester, Minnesota, USA.
² University of California San Francisco, San Francisco, California, USA.
³ Case Western Reserve University, Cleveland, Ohio, USA.
⁴ University of California Los Angeles, Los Angeles, California, USA.
⁵ University of Pennsylvania, Philadelphia, Pennsylvania, USA.
⁶ Tau Consortium, Rainwater Charitable Foundation, Fort Worth, Texas, USA.
⁷ University of Washington, Seattle, Washington, USA.
⁸ Harvard University/Massachusetts General Hospital, Boston, Massachusetts, USA.
⁹ Association for Frontotemporal Degeneration, Radnor, Pennsylvania, USA.
¹⁰ National Centralized Repository for Alzheimer's Disease and Related Dementias (NCRAD), Indiana University, Indianapolis, Indiana, USA.
¹¹ University of North Carolina, Chapel Hill, North Carolina, USA.
¹² Johns Hopkins University, Baltimore, Maryland, USA.
¹³ University of Toronto, Toronto, Ontario, Canada.
¹⁴ Washington University, St. Louis, Missouri, USA.
¹⁵ Columbia University, New York, New York, USA.
¹⁶ Mayo Clinic, Jacksonville, Florida, USA.
¹⁷ Northwestern University, Chicago, Illinois, USA.
¹⁸ University of British Columbia, Vancouver, British Columbia, Canada.
¹⁹ University of Texas Southwestern, Dallas, Texas, USA.
²⁰ National Alzheimer Coordinating Center (NACC), University of Washington, Seattle, Washington, USA.
²¹ University of California San Diego, San Diego, California, USA.
²² National Institute of Neurological Disorders and Stroke (NINDS), Bethesda, Maryland, USA.
²³ University of Alabama, Birmingham, Alabama, USA.
²⁴ Bluefield Project, San Francisco, California, USA.
²⁵ Laboratory of Neuroimaging (LONI), University of Southern California, Los Angeles, California, USA.

PMID: 31914218
PMCID: PMC7202045
DOI: 10.1002/alz.12033

Abstract

Introduction: We created global rating scoring rules for the CDR^® plus NACC FTLD to detect and track early frontotemporal lobar degeneration (FTLD) and to conduct clinical trials in FTLD.

Methods: The CDR plus NACC FTLD rating was applied to 970 sporadic and familial participants from the baseline visit of Advancing Research and Treatment in Frontotemporal Lobar Degeneration (ARTFL)/Longitudinal Evaluation of Familial Frontotemporal Dementia Subjects (LEFFTDS). Each of the eight domains of the CDR plus NACC FTLD was equally weighed in determining the global score. An interrater reliability study was completed for 40 participants.

Results: The CDR plus NACC FTLD showed very good interrater reliability. It was especially useful in detecting clinical features of mild non-fluent/agrammatic variant primary progressive aphasia participants.

Discussion: The global CDR plus NACC FTLD score could be an attractive outcome measure for clinical trials in symptomatic FTLD, and may be useful in natural history studies and clinical trials in FTLD spectrum disorders.

Keywords: CDR plus NACC FTLD; CDR®; behavior, comportment, and personality; frontotemporal lobar degeneration; global rating; language.

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Figures

**Figure 1.**
The scoring rules for determining the global CDR plus NACC FTLD score

**Figure 2.**
Distribution of global CDR and CDR plus NACC FTLD scores by diagnostic groups

See this image and copyright information in PMC

References

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Utility of the global CDR^® plus NACC FTLD rating and development of scoring rules: Data from the ARTFL/LEFFTDS Consortium

Affiliations

Utility of the global CDR^® plus NACC FTLD rating and development of scoring rules: Data from the ARTFL/LEFFTDS Consortium

Authors

Affiliations

Abstract

Figures

References

Publication types

MeSH terms

Grants and funding

LinkOut - more resources

Full Text Sources

Medical