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Case Reports
. 2019 Dec;20(6):412-415.
doi: 10.7181/acfs.2019.00430. Epub 2019 Dec 20.

Metachronous malignant tumors in ipsilateral salivary glands

Hyo Jeong Kwon  1 , Seong Ae Kim  1 , Jong Won Rhie  1 , Suk-Ho Moon  1
Affiliations
Case Reports

Metachronous malignant tumors in ipsilateral salivary glands

Hyo Jeong Kwon et al. Arch Craniofac Surg. 2019 Dec.

Abstract

Salivary gland tumors usually appear in solitary mass in single salivary gland. The coexistence of tumors with different histological types occurring within a unilateral parotid gland is an extremely rare event. We experienced a case which two different types of malignant tumors developed at different time points in same gland; metachronous tumors. The second tumor was excised widely and reconstruction was performed by free tissue transfer. Sensory and motor nerve to the left cheek appeared to be intact, and circulation was adequate. This rare case was presented in this article.

Keywords: Adenocarcinoma; Neoplasm, second primary; Salivary gland.

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Conflict of interest statement

Conflict of interest

No potential conflict of interest relevant to this article was reported.

Figures

Fig. 1.
Fig. 1.
Preoperative clinical photographs. (A) Anterior view and (B) lateral view.
Fig. 2.
Fig. 2.
Magnetic resonance imaging. (A) T1, coronal and (B) T2, axial.
Fig. 3.
Fig. 3.
Histologic findings. (A) A basal cell adenocarcinoma that exhibits invasive growth with associated perineural invasion (H&E, ×100). (B) The tumor is composed of basaloid cells, which occur concomitantly with vague two-cell morphologies (H&E, ×40).
Fig. 4.
Fig. 4.
Clinical photographs 12 months after surgery. (A) Anterior view and (B) lateral view.
See this image and copyright information in PMC

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References

    1. Whitt JC, Schafer DR, Callihan MD. Multiple malignant salivary gland neoplasms: mucoepidermoid carcinoma of palate and adenoid cystic carcinoma of floor of mouth. Head Neck Pathol. 2008;2:41–8. - PMC - PubMed
    1. Curry JL, Petruzzelli GJ, McClatchey KD, Lingen MW. Synchronous benign and malignant salivary gland tumors in ipsilateral glands: a report of two cases and a review of literature. Head Neck. 2002;24:301–6. - PubMed
    1. Ochal-Choinska A, Bruzgielewicz A, Osuch-Wojcikiewicz E. Synchronous multiple unilateral parotid gland tumors of benign and malignant histological types: case report and literature review. Braz J Otorhinolaryngol. 2019;85:388–92. - PMC - PubMed
    1. Franzen AM, Coordes A, Franzen CK, Guenzel T. Are multiple tumors of the parotid gland uncommon or underestimated? Anticancer Res. 2017;37:5263–7. - PubMed
    1. Ethunandan M, Pratt CA, Morrison A, Anand R, Macpherson DW, Wilson AW. Multiple synchronous and metachronous neoplasms of the parotid gland: the Chichester experience. Br J Oral Maxillofac Surg. 2006;44:397–401. - PubMed

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