Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2020 Jan 8;20(1):10.
doi: 10.1186/s12903-019-0998-8.

Assessment of the half-life of cationic periodontal pocket irrigation

Tugrul Kirtiloglu  1 , Ilker Keskiner  2 , Murathan Sahin  3 , Banu Kirtiloglu  4 , Safak Aygul  5 , Umur Sakallioglu  2 , Gokhan Acikgoz  6
Affiliations

Assessment of the half-life of cationic periodontal pocket irrigation

Tugrul Kirtiloglu et al. BMC Oral Health. .

Abstract

Background: The concentration and persisting time of antimicrobial agents in the periodontal pockets are important factors for their antimicrobial efficacy. Increased clearance time in the periodontal pocket is a significant criterion for the selection of intrapocket irrigants. The aim of this study was to estimate the clearance time of a cationic agent from the periodontal pocket.

Methods: Thallium-201(Tl-201) was chosen as a tracer to simulate the clearance of cationic substance because of its electrical activity. Twenty patients with periodontitis and probing depths 6 to 9 mm were included in this study. In each patient, 3 Mega Becquerel (MBq) of Tl-201 were inserted into the periodontal pocket. Dynamic imaging was performed and clearance of radioactivity was measured.

Results: Clearance of radioactivity was 67.1 ± 16.9, 83.1 ± 13.9, 90.4 ± 10.4, 93.39 ± 8.0% at 30, 60, 90 and 120 min, respectively. Half-life of wash-out was determined as 20.3 ± 10.2 min.

Conclusion: The results of this study demonstrate that the half-life of the cationic solution applied subgingivally was approximately 20 min and labelling of oral irrigants with radiotracers may be used to determine their clearance in further research.

Keywords: Cationic irrigation; Periodontal pocket; Scintigraphy; Tallium-201.

PubMed Disclaimer

Conflict of interest statement

The authors declare that they have no competing interests.

Figures

Fig. 1
Fig. 1
(Patient no. 14) Dynamic images
Fig. 2
Fig. 2
(Patient no. 14) Time-activity curve
See this image and copyright information in PMC

References

    1. Herrera D, Matesanz P, Bascones-Martinez A, Sanz M. Local and systemic antimicrobial therapy in periodontics. J Evid Based Dent Pract. 2012;12:50–60. doi: 10.1016/S1532-3382(12)70013-1. - DOI - PubMed
    1. Lecic J, Cakic S, Janjic Pavlovic O, Cicmil A, Vukotic O, Petrovic V, Cicmil S. Different methods for subgingival application of chlorhexidine in the treatment of patients with chronic periodontitis. Acta Odontol Scand. 2016;74:502–507. doi: 10.1080/00016357.2016.1206964. - DOI - PubMed
    1. Da Rocha HA, Silva CF, Santiago FL, Martins LG, Dias PC, De Magalhaes D. Local drug delivery systems in the treatment of periodontitis: a literature review. J Int Acad Periodontol. 2015;17:82–90. - PubMed
    1. Stabholz A, Nicholas AA, Zimmerman GJ, Wikesjo UME. Clinical and antimicrobial effects of a single episode of subgingival irrigation with tetracycline HCl or chlorhexidine in deep periodontal pockets. J Clin Periodontol. 1998;25:794–800. doi: 10.1111/j.1600-051X.1998.tb02372.x. - DOI - PubMed
    1. Tomasi C, Wennstrom JL. Locally delivered doxycycline as an adjunct to mechanical debridement at retreatment of periodontal pockets: outcome at furcation sites. J Periodontol. 2011;82:210–218. doi: 10.1902/jop.2010.100308. - DOI - PubMed

LinkOut - more resources