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. 2019 Nov 5;6(1):FSO431.
doi: 10.2144/fsoa-2019-0090.

Usefulness of TNFR1 as biomarker of intracranial aneurysm in patients with spontaneous subarachnoid hemorrhage

Reyes de Torres  1 , Fernando Mancha  2 , Alejandro Bustamante  3 , Patricia Canhao  4 , Isabel Fragata  5   6 , Joan Montaner  1   3
Affiliations

Usefulness of TNFR1 as biomarker of intracranial aneurysm in patients with spontaneous subarachnoid hemorrhage

Reyes de Torres et al. Future Sci OA. .

Abstract

Aim: To determine the utility of TNF-α receptor (TNFR1) as a biomarker for the presence of aneurysms in patients with acute subarachnoid hemorrhage (SAH).

Patient & methods: This is a prospective study in patients with acute spontaneous SAH. Arterial blood from catheter near aneurysm and peripheral venous blood samples are collected. TNFR1 levels were analyzed in patients with and without aneurysm.

Results: 80 patients were included, 58 were analyzed. 41 patients (70.7%) had an aneurysm. Venous TNFR1 levels >1658 pg/ml had 46.3% sensitivity and 94.1% specificity for aneurysms presence. TNFR1 >1658 pg/ml was also an independent predictor for its presence (odds ratio = 12.03 [1.13-128.16]; p = 0.039).

Conclusion: High levels of TNFR1 in peripheral venous blood are associated with the presence of aneurysm in patients with acute SAH.

Keywords: TNFR1; aneurysm; biomarker; spontaneous subarachnoid hemorrhage; stroke.

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Conflict of interest statement

Financial & competing interests disclosure This project was partially funded by the followings projects from ‘Instituto de Salud Carlos III’: INVICTUS+ (RD16/0019/0015); F Mancha is supported by Río Hortega research contract (CM16/00015) and A Bustamante is supported by a Juan Rodés research contract (JR16/00008). The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed. No writing assistance was utilized in the production of this manuscript.

Figures

Figure 1.
Figure 1.. Venous TNF-α receptor levels in patients with and without aneurysms.
(A) Boxplots represent median (interquartile range) of TNFR1 in patients with and without aneurysm. (B) Rates of patients with and without aneurysms among patients with TNFR1 <1658 pg/ml (light bars) and TNFR1 >1658 pg/ml (dark bars). *Outlier values. TNFR1: TNF-α receptor.
Figure 2.
Figure 2.. Receiver operating characteristics curve analysis and area under curve for the predictive value of venous TNF-α receptor for intracranial aneurysm presence.
See this image and copyright information in PMC

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