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Randomized Controlled Trial
. 2020 Apr;237(4):1121-1130.
doi: 10.1007/s00213-019-05442-6. Epub 2020 Jan 8.

Effects of short-term cannabidiol treatment on response to social stress in subjects at clinical high risk of developing psychosis

E Appiah-Kusi  1 , N Petros  1 , R Wilson  1 , M Colizzi  1   2 , M G Bossong  1   3 , L Valmaggia  4   5 , V Mondelli  5   6 , P McGuire  1   5 , S Bhattacharyya  7   8
Affiliations
Randomized Controlled Trial

Effects of short-term cannabidiol treatment on response to social stress in subjects at clinical high risk of developing psychosis

E Appiah-Kusi et al. Psychopharmacology (Berl). 2020 Apr.

Abstract

Rationale: Stress is a risk factor for psychosis and treatments which mitigate its harmful effects are needed. Cannabidiol (CBD) has antipsychotic and anxiolytic effects.

Objectives: We investigated whether CBD would normalise the neuroendocrine and anxiety responses to stress in clinical high risk for psychosis (CHR) patients.

Methods: Thirty-two CHR patients and 26 healthy controls (HC) took part in the Trier Social Stress Test (TSST) and their serum cortisol, anxiety and stress associated with public speaking were estimated. Half of the CHR participants were on 600 mg/day of CBD (CHR-CBD) and half were on placebo (CHR-P) for 1 week.

Results: One-way analysis of variance (ANOVA) revealed a significant effect of group (HC, CHR-P, CHR-CBD (p = .005) on cortisol reactivity as well as a significant (p = .003) linear decrease. The change in cortisol associated with experimental stress exposure was greatest in HC controls and least in CHR-P patients, with CHR-CBD patients exhibiting an intermediate response. Planned contrasts revealed that the cortisol reactivity was significantly different in HC compared with CHR-P (p = .003), and in HC compared with CHR-CBD (p = .014), but was not different between CHR-P and CHR-CBD (p = .70). Across the participant groups (CHR-P, CHR-CBD and HC), changes in anxiety and experience of public speaking stress (all p's < .02) were greatest in the CHR-P and least in the HC, with CHR-CBD participants demonstrating an intermediate level of change.

Conclusions: Our findings show that it is worthwhile to design further well powered studies which investigate whether CBD may be used to affect cortisol response in clinical high risk for psychosis patients and any effect this may have on symptoms.

Keywords: Cannabidiol; Psychosis; Trier Social Stress Test; Ultra-high risk.

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Conflict of interest statement

The authors declare that they have no conflict of interest.

Figures

Fig. 1
Fig. 1
Timing of procedures for TSST
Fig. 2
Fig. 2
Group-dependent cortisol reaction
Fig. 3
Fig. 3
Group-dependent experience of anxiety
See this image and copyright information in PMC

References

    1. Appiah-Kusi E, Leyden E, Parmar S, Mondelli V, McGuire P, Bhattacharyya S. Abnormalities in neuroendocrine stress response in psychosis: the role of endocannabinoids. Psychol Med. 2016;46:27–45. doi: 10.1017/S0033291715001786. - DOI - PubMed
    1. Beards S, Gayer-Anderson C, Borges S, Dewey ME, Fisher HL, Morgan C. Life events and psychosis: a review and meta-analysis. Schizophr Bull. 2013;39:740–747. doi: 10.1093/schbul/sbt065. - DOI - PMC - PubMed
    1. Bebbington P, Nayani T. The psychosis screening questionnaire. International Journal of: Methods in Psychiatric Research; 1995.
    1. Bergamaschi MM, Queiroz RHC, Chagas MHN, De Oliveira DCG, De Martinis BS, Kapczinski F, Quevedo J, Roesler R, Schröder N, Nardi AE. Cannabidiol reduces the anxiety induced by simulated public speaking in treatment-naive social phobia patients. Neuropsychopharmacology. 2011;36:1219–1226. doi: 10.1038/npp.2011.6. - DOI - PMC - PubMed
    1. Bergamaschi M, Mateus, Queiroz RHC, Zuardi AW, Crippa AS. Safety and side effects of cannabidiol, a Cannabis sativa constituent. Curr Drug Saf. 2011;6:237–249. doi: 10.2174/157488611798280924. - DOI - PubMed

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