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. 2020 Feb;43(2):79-81.
doi: 10.1016/j.tins.2019.12.002. Epub 2020 Jan 6.

The Sigma-1 Receptor at the Crossroad of Proteostasis, Neurodegeneration, and Autophagy

Maximilian G Christ  1 , Albrecht M Clement  1 , Christian Behl  2
Affiliations

The Sigma-1 Receptor at the Crossroad of Proteostasis, Neurodegeneration, and Autophagy

Maximilian G Christ et al. Trends Neurosci. 2020 Feb.

Abstract

Neurodegenerative diseases are linked to dysfunctional proteostasis and disturbed autophagy. Here, we discuss how the sigma-1 receptor (Sig-1R) may act at the intersection of this interaction, as loss-of-function mutations of this unique chaperone are associated with defective autophagy and its pharmacological activation induces autophagic activity.

Keywords: ALS; ER; autophagy; neurodegeneration; sigma-1 receptor.

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