Elite Intratumoral T-cell Clonotypes (The 1%) Effect "Trickle-Down Cytotoxicity"

Abstract

Careful study of T-cell clonal dynamics in patients with non-small cell lung cancer treated with neoadjuvant nivolumab suggests that successful trafficking of clones from a proliferative burst in the periphery to the tumor associates with major pathologic response. Integration of these findings with functional analysis may augment current therapeutic strategies.See related article by Zhang et al., p. 1327.