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. 2020 Jan;28(1):15-24.
doi: 10.1016/j.jsps.2019.11.002. Epub 2019 Nov 13.

Synthesis and characterization of mesoporous SBA-15 and SBA-16 as carriers to improve albendazole dissolution rate

María Esperanza Adrover  1   2 , Marisa Pedernera  1   2 , Magali Bonne  3   4 , Bénédicte Lebeau  3   4 , Verónica Bucalá  1   2 , Loreana Gallo  5   2
Affiliations

Synthesis and characterization of mesoporous SBA-15 and SBA-16 as carriers to improve albendazole dissolution rate

María Esperanza Adrover et al. Saudi Pharm J. 2020 Jan.

Abstract

Albendazole (ABZ, anti-parasitic active pharmaceutical ingredient) is a crystalline low water-soluble drug, thus the dissolution rate in gastrointestinal fluids is limited. Consequently, the improvement of the water solubility and dissolution rate of ABZ implies a great challenge for a more efficient treatment of hydatidosis. In this context, SBA-15 and SBA-16 ordered mesoporous silica materials were synthetized and loaded with ABZ. X-ray diffraction, FT-IR spectroscopy, nitrogen physisorption manometry, particle size distribution and scanning electronic microscopy were used to characterize unloaded and loaded materials (ABZ/SBA-15 and ABZ/SBA-16). The loaded ABZ amount in the carriers was estimated by elemental analysis. For the loaded materials, the drug solubility and release profile were evaluated. In addition, mathematical models were compared to explain the dissolution kinetics of ABZ from mesoporous solids. ABZ was successfully loaded into the mesopores. The amorphous state of the adsorbed ABZ was confirmed by differential scanning calorimetry that resulted in a notable increment in the dissolution rate compared to crystalline ABZ. Drug release behaviors were well simulated by the Weibull model for ABZ/SBA-15 and by the Gompertz function for pure ABZ and ABZ/SBA-16. The SBA-15 carrier exhibited the highest drug loading and dissolution rate becoming a promising material to improve ABZ bioavailability.

Keywords: Albendazole; Dissolution rate; Drug loading; Mesoporous materials; Solubility.

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Conflict of interest statement

The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

Figures

Fig. 1
Fig. 1
XRD diffraction patterns of: (a) SBA-15 and (b) SBA-16.
Fig. 2
Fig. 2
SEM images: (a) SBA-15 (2000x) and (b) SBA-16 (480x). TEM images (270000x): at vertical orientation (c) SBA-15, (e) SBA-16 and at parallel orientation d) SBA-15, f) SBA-16.
Fig. 3
Fig. 3
FT-IR spectra of (a) ABZ, (b) SBA-15 and SBA-16, and (c) SBA-15/ABZ and SBA-16/ABZ.
Fig. 4
Fig. 4
Nitrogen sorption isotherms and pore size distribution (inset) of: (a) SBA-15 and ABZ/SBA-15 and (b) SBA-16 and ABZ/SBA-16.
Fig. 5
Fig. 5
DSC patterns of ABZ, SBA-15, SBA-16, ABZ/SBA-15 and ABZ/SBA-16.
Fig. 6
Fig. 6
Release profiles of pure ABZ, ABZ/SBA-15 and ABZ/SBA-16.
See this image and copyright information in PMC

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