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. 2019 Dec 19:12:313.
doi: 10.3389/fnmol.2019.00313. eCollection 2019.

Inhibitory Receptor Diffusion Dynamics

Stephanie A Maynard  1 , Antoine Triller  1
Affiliations

Inhibitory Receptor Diffusion Dynamics

Stephanie A Maynard et al. Front Mol Neurosci. .

Abstract

The dynamic modulation of receptor diffusion-trapping at inhibitory synapses is crucial to synaptic transmission, stability, and plasticity. In this review article, we will outline the progression of understanding of receptor diffusion dynamics at the plasma membrane. We will discuss how regulation of reversible trapping of receptor-scaffold interactions in combination with theoretical modeling approaches can be used to quantify these chemical interactions at the postsynapse of living cells.

Keywords: GABAA receptor; diffusion-trapping; gephyrin; glycine receptor; inhibitory synapse; single-particle tracking.

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Figures

Figure 1
Figure 1
Inhibitory receptor diffusion-trapping. (1) Overview schematic of pre- and postsynaptic inhibitory neuronal membranes, exocytosis, and lateral diffusion. (2) The dynamic equilibrium between stabilized and freely mobile receptors, at the synapse and extrasynaptically, respectively. (3) Receptor diffusion-trapping depends not only on chemical interactions with synaptic components but also on non-specific obstacles, such as lipid rafts, leading to molecular crowding. (4) Activity regulation of receptor mobility can affect post-translational modifications of receptors and scaffold proteins and subsequently their immobilization at synapses. Exchange of receptors between synapses can fine-tune network activity.
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