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. 2019 Dec 11:10:856.
doi: 10.3389/fendo.2019.00856. eCollection 2019.

Can Reverse T3 Assay Be Employed to Guide T4 vs. T4/T3 Therapy in Hypothyroidism?

Cristiane Gomes-Lima  1 , Leonard Wartofsky  2 , Kenneth Burman  3
Affiliations

Can Reverse T3 Assay Be Employed to Guide T4 vs. T4/T3 Therapy in Hypothyroidism?

Cristiane Gomes-Lima et al. Front Endocrinol (Lausanne). .
No abstract available

Keywords: T4/T3 combination; combination therapy; deiodinase 3; deiodinases; hypothyroidism; reverse T3; thyroid hormones.

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Figures

Figure 1
Figure 1
Structure of thyroxine (T4) and the deiodinative cascade to T3 and reverse T3 (rT3). This figure was obtained with permission from Gomes-Lima and Burman (4). Copyright © 2018 The Cleveland Clinic Foundation. All rights reserved.
Figure 2
Figure 2
Individual values of serum reverse T3 levels in normal, hypothyroid, and hyperthyroid subjects and in athyreotic patients who have been administered 50 mcg of LT4 and 400 mcg of LT4 daily [This figure was obtained with permission from Burman et al. (9)].
See this image and copyright information in PMC

References

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    1. Engler D, Burger AG. The deiodination of the iodothyronines and of their derivatives in man. Endocr Rev. (1984) 5:151–84. 10.1210/edrv-5-2-151 - DOI - PubMed
    1. Bianco AC, Salvatore D, Gereben B, Berry MJ, Larsen PR. Biochemistry, cellular and molecular biology, and physiological roles of the iodothyronine selenodeiodinases. Endocr Rev. (2002) 23:38–89. 10.1210/edrv.23.1.0455 - DOI - PubMed
    1. Gomes-Lima C, Burman KD. Reverse T3 or perverse T3? Still puzzling after 40 years. Cleve Clin J Med. (2018) 85:450–5. 10.3949/ccjm.85a.17079 - DOI - PubMed
    1. Dentice M, Salvatore D. Deiodinases: the balance of thyroid hormone: local impact of thyroid hormone inactivation. J Endocrinol. (2011) 209:273–82. 10.1530/JOE-11-0002 - DOI - PubMed

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