Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2019 Dec 17:9:1449.
doi: 10.3389/fonc.2019.01449. eCollection 2019.

Role of Regenerating Islet-Derived Protein 3A in Gastrointestinal Cancer

Meng-Ya Zhang  1   2 , Jun Wang  1   2 , Jie Guo  1   2
Affiliations
Review

Role of Regenerating Islet-Derived Protein 3A in Gastrointestinal Cancer

Meng-Ya Zhang et al. Front Oncol. .

Abstract

Regenerating islet-derived protein 3A (Reg3A), a protein mainly expressed in the digestive system, has been found over-expressed in many kinds of gastrointestinal cancer, including hepatocellular carcinoma, pancreatic cancer, gastric cancer, and colorectal cancer, therefore has been considered as a promising tumor marker. In recent years, considerable attention has been focused on the tumorigenesis effects of Reg3A, which were mainly manifested as cell proliferation promotion, cell apoptosis inhibition, the regulation of cancer cell migration and invasion. In particular, based on the significant up-regulation of Reg3A during pancreatic inflammation as well as its tumorigenic potential, Reg3A has been considered to play a key role in inflammation-linked pancreatic carcinogenesis. In addition, we here systematically generalized the reported Reg3A-related signaling molecules, which included JAK2-STAT3- NF-κB, SOCS3, EXTL3-PI3K-Akt, GSK3β, Wnt/β-catenin as well as some invasion and migration-related genes (Snail, MMP-2, MMP-9, E-cadherin, RhoC, and MTA1). And gp130, EGFR, EXTL3, and Fibronectin 1 might act as potential receptors for Reg3A.

Keywords: apoptosis; gastrointestinal cancer; inflammation; invasion; proliferation; regenerating islet-derived protein 3A.

PubMed Disclaimer

Figures

Figure 1
Figure 1
Role and its underlying mechanisms of Reg3A for carcinogenesis of gastrointestinal cancer.
See this image and copyright information in PMC

References

    1. Kinoshita Y, Ishihara S, Kadowaki Y, Fukui H, Chiba T. Reg protein is a unique growth factor of gastric mucosal cells. J Gastroenterol. (2004) 39:507–13. 10.1007/s00535-004-1354-5 - DOI - PubMed
    1. Parikh A, Stephan AF, Tzanakakis ES. Regenerating proteins and their expression, regulation and signaling. Biomol Concepts. (2012) 3:57–70. 10.1515/bmc.2011.055 - DOI - PMC - PubMed
    1. Zenilman ME, Tuchman D, Zheng Q, Levine J, Delany H. Comparison of reg I and reg III levels during acute pancreatitis in the rat. Ann Surg. (2000) 232:646–52. 10.1097/00000658-200011000-00005 - DOI - PMC - PubMed
    1. Yin G, Du J, Cao H, Liu X, Xu Q, Xiang M. Reg3g promotes pancreatic carcinogenesis in a murine model of chronic pancreatitis. Dig Dis Sci. (2015) 60:3656–68. 10.1007/s10620-015-3787-5 - DOI - PubMed
    1. Wang Y, Jacovetti C, Li B, Siddique T, Xiong X, Yin H, et al. . Coordinated age-dependent and pancreatic-specific expression of mouse Reg2Reg3alpha, and Reg3beta genes. Growth Factors. (2011) 29:72–81. 10.3109/08977194.2011.562866 - DOI - PubMed