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. 2020 Aug 15;147(4):978-989.
doi: 10.1002/ijc.32863. Epub 2020 Jan 21.

Gallbladder and extrahepatic bile duct cancers in the Americas: Incidence and mortality patterns and trends

Adalberto Miranda-Filho  1 , Marion Piñeros  1 , Catterina Ferreccio  2 , Volkan Adsay  3 , Isabelle Soerjomataram  1 , Freddie Bray  1 , Jill Koshiol  4
Affiliations

Gallbladder and extrahepatic bile duct cancers in the Americas: Incidence and mortality patterns and trends

Adalberto Miranda-Filho et al. Int J Cancer. .

Abstract

Trends in gallbladder cancer incidence and mortality in populations across the Americas can provide insight into shifting epidemiologic patterns and the current and potential impact of preventative and curative programs. Estimates of gallbladder and extrahepatic bile duct cancer incidence and mortality for the year 2018 were extracted from International Agency for Research on Cancer (IARC) GLOBOCAN database for 185 countries. Recorded registry-based incidence from 13 countries was extracted from IARCs Cancer Incidence in Five Continents series and corresponding national deaths from the WHO mortality database. Among females, the highest estimated incidence for gallbladder and extrahepatic bile duct cancer in the Americas were found in Bolivia (21.0 per 100,000), Chile (11.7) and Peru (6.0). In the US, the highest incidence rates were observed among Hispanics (1.8). In the Chilean population, gallbladder cancer rates declined in both females and males between 1998 and 2012. Rates dropped slightly in Canada, Costa Rica, US Whites and Hispanics in Los Angeles. Gallbladder cancer mortality rates also decreased across the studied countries, although rising trends were observed in Colombia and Canada after 2010. Countries within Southern and Central America tended to have a higher proportion of unspecified biliary tract cancers. In public health terms, the decline in gallbladder cancer incidence and mortality rates is encouraging. However, the slight increase in mortality rates during recent years in Colombia and Canada warrant further attention. Higher proportions of unspecified biliary tract cancers (with correspondingly higher mortality rates) suggest more rigorous pathology procedures may be needed after surgery.

Keywords: ampulla of Vater; carcinomas of gallbladder; extrahepatic and biliary duct cancers; incidence; mortality.

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Conflict of interest statement

Conflict of interest

None

Figures

Figure 1.
Figure 1.
Global map of estimated age-standardized A) incidence and B) mortality rates per 100,000 of biliary tract cancers (C23–24) by sex, all ages, 2018.
Figure 2.
Figure 2.
Age-standardized incidence rates of gallbladder, extrahepatic duct, ampulla of Vater, and other and unspecified morphology biliary tract cancers in the Americas, in females (blue bars) and males (blue bars), circa 2008–2012.
Figure 3.
Figure 3.
Proportion of gallbladder, extrahepatic duct, ampulla of Vater, and other and unspecified biliary tract cancers, in females and males by populations in the Americas, circa 2008–2012.
Figure 4.
Figure 4.
Time trends in age-standardized incidence rates of gallbladder cancer (C23) in selected populations in the Americas, females and males, all ages, 1980–2012. Source: Cancer Incidence in Five Continents.
Figure 5.
Figure 5.
Time trends in age-standardized mortality rates of gallbladder cancer (C23) in selected countries in the Americas, females and males, all ages, 1980–2012.
See this image and copyright information in PMC

References

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