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. 2020 May 1;201(9):1155-1157.
doi: 10.1164/rccm.201911-2149LE.

Optimizing β-Lactams against Tuberculosis

Veronique R de Jager  1 , Naadira Vanker  2 , Lize van der Merwe  1 , Elana van Brakel  1 , Morris Muliaditan  3 , Andreas H Diacon  1   4
Affiliations

Optimizing β-Lactams against Tuberculosis

Veronique R de Jager et al. Am J Respir Crit Care Med. .
No abstract available

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Figures

Figure 1.
Figure 1.
Fourteen-day mycobactericidal activity of intravenous meropenem (Mero) 6 g once daily over 6 hours versus 2 g every 8 hours, compared with that of ertapenem (Erta) 1 g once daily intramuscularly and isoniazid, rifampicin, pyrazinamide, and ethambutol (HRZE) dosed once daily according to standard weight bands. All Mero- and Erta-containing groups received amoxicillin plus clavulanic acid orally twice daily. The darker blue lines represent the estimated daily on-treatment change in colony-forming units [log10cfu], adjusted for baseline cfu, age, body mass index, sex, and study. The lighter blue shadows are the associated 95% confidence bands. The solid squares represent the time point of sputum collection. We used a single joint linear mixed-effects model, taking into account the correlation between observations from each participant.
See this image and copyright information in PMC

References

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