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Review
. 2020 Jul;30(4):489-496.
doi: 10.1111/ipd.12615. Epub 2020 Jan 24.

Treatment for oral lesions in pediatric patients with Stevens-Johnson's syndrome: A case report and literature review

Natalia Barea-Jiménez  1 , Javier Calero  1 , Damaris Molina-Negrón  1 , Lydia M López Del-Valle  2
Affiliations
Review

Treatment for oral lesions in pediatric patients with Stevens-Johnson's syndrome: A case report and literature review

Natalia Barea-Jiménez et al. Int J Paediatr Dent. 2020 Jul.

Abstract

Stevens-Johnson syndrome (SJS) is a disorder forming one of the several severe cutaneous adverse reactions, a group that includes, as well, erythema multiforme, toxic epidermal necrolysis (TEN), and SJS/TEN overlap. These adverse reactions are characterized by their severe involvement of the skin and the oral, gastrointestinal, genital, and conjunctival mucosa. The purposes of the study described herein were to perform a literature review of studies describing the clinical presentations and management of SJS patients with oral manifestations and to present a case report of a patient treated with dapsone gel. The research question for the literature review was the following: For patients with SJS, does adjunctive topical antibiotic treatment provide a better resolution for oral lesions than supportive care does? An online search of studies published from 2000 to 2019 was performed using the following databases: PubMed, BBO, LILACS, the Cochrane Library, and Ovid MEDLINE. Eight case reports were identified that met the inclusion criteria. Most of the articles included information about palliative treatments, such as supragingival cleaning and debridement, and the use of palliative oral rinses and gels, such as 'magic' mouthwash, chlorhexidine 0.12%, and lidocaine 2% gel. The case reported added an innovative treatment consisting of dapsone gel 5%.

Keywords: Stevens-Johnson syndrome; dapsone 5%; oral manifestations; toxic epidermal necrolysis; treatment.

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References

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