Standardisation of nailfold capillaroscopy for the assessment of patients with Raynaud's phenomenon and systemic sclerosis

Vanessa Smith¹, Ariane L Herrick², Francesca Ingegnoli³, Nemanja Damjanov⁴, Rossella De Angelis⁵, Christopher P Denton⁶, Oliver Distler⁷, Karinna Espejo⁸, Ivan Foeldvari⁹, Tracy Frech¹⁰, Boris Garro¹¹, Marwin Gutierrez¹², Genevieve Gyger¹³, Eric Hachulla¹⁴, Roger Hesselstrand¹⁵, Annamaria Iagnocco¹⁶, Cristiane Kayser¹⁷, Karin Melsens¹⁸, Ulf Müller-Ladner¹⁹, Sabrina Paolino²⁰, Carmen Pizzorni²¹, Mislav Radic²², Valeria Riccieri²³, Marcus Snow²⁴, Wendy Stevens²⁵, Alberto Sulli²⁶, Jacob M van Laar²⁷, Madelon C Vonk²⁸, Amber Vanhaecke²⁹, Maurizio Cutolo³⁰; EULAR Study Group on Microcirculation in Rheumatic Diseases and the Scleroderma Clinical Trials Consortium Group on Capillaroscopy

Affiliations

¹ Department of Internal Medicine, Ghent University, Ghent, Belgium; Department of Rheumatology, Ghent University Hospital, Ghent, Belgium; Unit for Molecular Immunology and Inflammation, VIB Inflammation Research Center (IRC), Ghent, Belgium. Electronic address: vanessa.smith@ugent.be.
² Division of Musculoskeletal & Dermatological Sciences, The University of Manchester, Salford Royal NHS Foundation Trust, Manchester, UK; NIHR Manchester Biomedical Research Centre, Manchester University NHS Foundation Trust, Manchester Academic Health Science Centre, Manchester, UK. Electronic address: ariane.herrick@manchester.ac.uk.
³ Department of Clinical Sciences and Community Health, University of Milan, Milan, Italy; Division of Rheumatology, ASST G. Pini, Milan, Italy. Electronic address: francesca.ingegnoli@unimi.it.
⁴ Institute of Rheumatology, University of Belgrade Medical School, Belgrade, Serbia. Electronic address: nemanjadamjanov@yahoo.com.
⁵ Department of Clinical and Molecular Sciences, Rheumatology Unit, Carlo Urbani Hospital, Polytechnic University of Marche, Jesi, Ancona, Italy. Electronic address: rossella.deangelis@sanita.marche.it.
⁶ Department of Rheumatology, University College London, Royal Free Hospital, London, UK. Electronic address: c.denton@medsch.ucl.ac.uk.
⁷ Department of Rheumatology, University Hospital Zurich, Zurich, Switzerland. Electronic address: oliver.distler@usz.ch.
⁸ Universidad Peruana De Ciencias Aplicadas (UPC), Centro de Excelencia en Reumatología (CER-PERU), Lima, Peru. Electronic address: krev76@gmail.com.
⁹ Centre for Paediatric and Adolescent Rheumatology, Hamburg, Germany. Electronic address: foeldvari@t-online.de.
¹⁰ Department of Rheumatology, University of Utah, Salt Lake City, Utah, USA. Electronic address: tracy.frech@hsc.utah.edu.
¹¹ Universidad Peruana De Ciencias Aplicadas (UPC), Centro de Excelencia en Reumatología (CER-PERU), Lima, Peru. Electronic address: bgarrob1@gmail.com.
¹² Division of Musculoskeletal and Rheumatic Disorders, Instituto Nacional de Rehabilitación, Mexico City, Mexico. Electronic address: dr.gmarwin@gmail.com.
¹³ Division of Rheumatology, Jewish General Hospital, Department of Medicine, McGill University, Montreal, Quebec, Canada. Electronic address: gengyger@hotmail.com.
¹⁴ Univ. Lille, CHU Lille, Département de Médecine Interne et Immunologie Clinique, Centre de Référence des Maladies Systémiques et Auto-Immunes Rares du Nord-Ouest (CERAINO), LIRIC, INSERM, Lille, France. Electronic address: ehachulla2@yahoo.fr.
¹⁵ Department of Rheumatology, Skåne University Hospital, Lund University, Lund, Sweden. Electronic address: roger.hesselstrand@med.lu.se.
¹⁶ Academic Rheumatology Center, Department of Clinical and Biological Science, University of Turin, Turin, Italy. Electronic address: annamaria.iagnocco1@gmail.com.
¹⁷ Rheumatology Division, Escola Paulista de Medicina, Universidade Federal de São Paulo, São Paulo, Brazil. Electronic address: cristiane.kayser@unifesp.br.
¹⁸ Department of Internal Medicine, Ghent University, Ghent, Belgium; Department of Rheumatology, Ghent University Hospital, Ghent, Belgium. Electronic address: karin.melsens@ugent.be.
¹⁹ Department of Rheumatology and Clinical Immunology, Justus-Liebig University of Giessen, Campus Kerckhoff, Bad Nauheim, Germany. Electronic address: u.mueller-ladner@kerckhoff-klinik.de.
²⁰ Research Laboratory and Academic Division of Clinical Rheumatology, Department of Internal Medicine, University of Genoa, IRCCS San Martino Polyclinic Hospital, Genoa, Italy. Electronic address: sabrina.paolino@unige.it.
²¹ Research Laboratory and Academic Division of Clinical Rheumatology, Department of Internal Medicine, University of Genoa, IRCCS San Martino Polyclinic Hospital, Genoa, Italy. Electronic address: carmen.pizzorni@unige.it.
²² Division of Rheumatology and Clinical Immunology, University Hospital Split, Split, Croatia. Electronic address: mislavradic@gmail.com.
²³ Department of Internal Medicine and Medical Specialties, Sapienza University of Rome, Rome, Italy. Electronic address: valeria.riccieri@uniroma1.it.
²⁴ Department of Internal Medicine, Division of Rheumatology, University of Nebraska Medical Center, Omaha, NE, USA. Electronic address: msnow@unmc.edu.
²⁵ Department of Rheumatology, St Vincent's Hospital, Melbourne, Victoria, Australia. Electronic address: wendy.stevens@bigpond.com.
²⁶ Research Laboratory and Academic Division of Clinical Rheumatology, Department of Internal Medicine, University of Genoa, IRCCS San Martino Polyclinic Hospital, Genoa, Italy. Electronic address: albertosulli@unige.it.
²⁷ Department of Rheumatology and Clinical Immunology, University Medical Center Utrecht, Utrecht, The Netherlands. Electronic address: j.m.vanlaar@umcutrecht.nl.
²⁸ Department of Rheumatology, Radboud University Medical Center, Nijmegen, The Netherlands. Electronic address: madelon.vonk@radboudumc.nl.
²⁹ Department of Internal Medicine, Ghent University, Ghent, Belgium; Department of Rheumatology, Ghent University Hospital, Ghent, Belgium. Electronic address: amber.vanhaecke@ugent.be.
³⁰ Research Laboratory and Academic Division of Clinical Rheumatology, Department of Internal Medicine, University of Genoa, IRCCS San Martino Polyclinic Hospital, Genoa, Italy. Electronic address: mcutolo@unige.it.

PMID: 31927087
DOI: 10.1016/j.autrev.2020.102458

Free article

Review

Standardisation of nailfold capillaroscopy for the assessment of patients with Raynaud's phenomenon and systemic sclerosis

Vanessa Smith et al. Autoimmun Rev. 2020 Mar.

Free article

. 2020 Mar;19(3):102458.

doi: 10.1016/j.autrev.2020.102458. Epub 2020 Jan 10.

Authors

Affiliations

¹ Department of Internal Medicine, Ghent University, Ghent, Belgium; Department of Rheumatology, Ghent University Hospital, Ghent, Belgium; Unit for Molecular Immunology and Inflammation, VIB Inflammation Research Center (IRC), Ghent, Belgium. Electronic address: vanessa.smith@ugent.be.
² Division of Musculoskeletal & Dermatological Sciences, The University of Manchester, Salford Royal NHS Foundation Trust, Manchester, UK; NIHR Manchester Biomedical Research Centre, Manchester University NHS Foundation Trust, Manchester Academic Health Science Centre, Manchester, UK. Electronic address: ariane.herrick@manchester.ac.uk.
³ Department of Clinical Sciences and Community Health, University of Milan, Milan, Italy; Division of Rheumatology, ASST G. Pini, Milan, Italy. Electronic address: francesca.ingegnoli@unimi.it.
⁴ Institute of Rheumatology, University of Belgrade Medical School, Belgrade, Serbia. Electronic address: nemanjadamjanov@yahoo.com.
⁵ Department of Clinical and Molecular Sciences, Rheumatology Unit, Carlo Urbani Hospital, Polytechnic University of Marche, Jesi, Ancona, Italy. Electronic address: rossella.deangelis@sanita.marche.it.
⁶ Department of Rheumatology, University College London, Royal Free Hospital, London, UK. Electronic address: c.denton@medsch.ucl.ac.uk.
⁷ Department of Rheumatology, University Hospital Zurich, Zurich, Switzerland. Electronic address: oliver.distler@usz.ch.
⁸ Universidad Peruana De Ciencias Aplicadas (UPC), Centro de Excelencia en Reumatología (CER-PERU), Lima, Peru. Electronic address: krev76@gmail.com.
⁹ Centre for Paediatric and Adolescent Rheumatology, Hamburg, Germany. Electronic address: foeldvari@t-online.de.
¹⁰ Department of Rheumatology, University of Utah, Salt Lake City, Utah, USA. Electronic address: tracy.frech@hsc.utah.edu.
¹¹ Universidad Peruana De Ciencias Aplicadas (UPC), Centro de Excelencia en Reumatología (CER-PERU), Lima, Peru. Electronic address: bgarrob1@gmail.com.
¹² Division of Musculoskeletal and Rheumatic Disorders, Instituto Nacional de Rehabilitación, Mexico City, Mexico. Electronic address: dr.gmarwin@gmail.com.
¹³ Division of Rheumatology, Jewish General Hospital, Department of Medicine, McGill University, Montreal, Quebec, Canada. Electronic address: gengyger@hotmail.com.
¹⁴ Univ. Lille, CHU Lille, Département de Médecine Interne et Immunologie Clinique, Centre de Référence des Maladies Systémiques et Auto-Immunes Rares du Nord-Ouest (CERAINO), LIRIC, INSERM, Lille, France. Electronic address: ehachulla2@yahoo.fr.
¹⁵ Department of Rheumatology, Skåne University Hospital, Lund University, Lund, Sweden. Electronic address: roger.hesselstrand@med.lu.se.
¹⁶ Academic Rheumatology Center, Department of Clinical and Biological Science, University of Turin, Turin, Italy. Electronic address: annamaria.iagnocco1@gmail.com.
¹⁷ Rheumatology Division, Escola Paulista de Medicina, Universidade Federal de São Paulo, São Paulo, Brazil. Electronic address: cristiane.kayser@unifesp.br.
¹⁸ Department of Internal Medicine, Ghent University, Ghent, Belgium; Department of Rheumatology, Ghent University Hospital, Ghent, Belgium. Electronic address: karin.melsens@ugent.be.
¹⁹ Department of Rheumatology and Clinical Immunology, Justus-Liebig University of Giessen, Campus Kerckhoff, Bad Nauheim, Germany. Electronic address: u.mueller-ladner@kerckhoff-klinik.de.
²⁰ Research Laboratory and Academic Division of Clinical Rheumatology, Department of Internal Medicine, University of Genoa, IRCCS San Martino Polyclinic Hospital, Genoa, Italy. Electronic address: sabrina.paolino@unige.it.
²¹ Research Laboratory and Academic Division of Clinical Rheumatology, Department of Internal Medicine, University of Genoa, IRCCS San Martino Polyclinic Hospital, Genoa, Italy. Electronic address: carmen.pizzorni@unige.it.
²² Division of Rheumatology and Clinical Immunology, University Hospital Split, Split, Croatia. Electronic address: mislavradic@gmail.com.
²³ Department of Internal Medicine and Medical Specialties, Sapienza University of Rome, Rome, Italy. Electronic address: valeria.riccieri@uniroma1.it.
²⁴ Department of Internal Medicine, Division of Rheumatology, University of Nebraska Medical Center, Omaha, NE, USA. Electronic address: msnow@unmc.edu.
²⁵ Department of Rheumatology, St Vincent's Hospital, Melbourne, Victoria, Australia. Electronic address: wendy.stevens@bigpond.com.
²⁶ Research Laboratory and Academic Division of Clinical Rheumatology, Department of Internal Medicine, University of Genoa, IRCCS San Martino Polyclinic Hospital, Genoa, Italy. Electronic address: albertosulli@unige.it.
²⁷ Department of Rheumatology and Clinical Immunology, University Medical Center Utrecht, Utrecht, The Netherlands. Electronic address: j.m.vanlaar@umcutrecht.nl.
²⁸ Department of Rheumatology, Radboud University Medical Center, Nijmegen, The Netherlands. Electronic address: madelon.vonk@radboudumc.nl.
²⁹ Department of Internal Medicine, Ghent University, Ghent, Belgium; Department of Rheumatology, Ghent University Hospital, Ghent, Belgium. Electronic address: amber.vanhaecke@ugent.be.
³⁰ Research Laboratory and Academic Division of Clinical Rheumatology, Department of Internal Medicine, University of Genoa, IRCCS San Martino Polyclinic Hospital, Genoa, Italy. Electronic address: mcutolo@unige.it.

PMID: 31927087
DOI: 10.1016/j.autrev.2020.102458

Abstract

Capillaroscopy is a non-invasive and safe tool which allows the evaluation of the morphology of the microcirculation. Since its recent incorporation in the 2013 American College of Rheumatology (ACR)/European League Against Rheumatism (EULAR) classification criteria for systemic sclerosis together with its assessed role to monitor disease progression, capillaroscopy became a 'mainstream' investigation for rheumatologists. Given its increasing use by a variety of physicians internationally both in daily practice to differentiate primary from secondary Raynaud's phenomenon, as well as in research context to predict disease progression and monitor treatment effects, standardisation in capillaroscopic image acquisition and analysis seems paramount. To step forward to this need, experts in the field of capillaroscopy/microcirculation provide in this very consensus paper their view on image acquisition and analysis, different capillaroscopic techniques, normal and abnormal capillaroscopic characteristics and their meaning, scoring systems and reliability of image acquisition and interpretation.

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Standardisation of nailfold capillaroscopy for the assessment of patients with Raynaud's phenomenon and systemic sclerosis

Affiliations

Standardisation of nailfold capillaroscopy for the assessment of patients with Raynaud's phenomenon and systemic sclerosis

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Abstract

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LinkOut - more resources

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Medical