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. 2020 Mar 6;85(5):3110-3124.
doi: 10.1021/acs.joc.9b03011. Epub 2020 Jan 27.

Deoxofluorination of (Hetero)aromatic Acids

Serhii Trofymchuk  1 , Maksym Ya Bugera  1   2 , Anton A Klipkov  1   2 , Bohdan Razhyk  1 , Sergey Semenov  1 , Karen Tarasenko  2   3 , Viktoriia S Starova  4 , Olga A Zaporozhets  4 , Oksana Yu Tananaiko  4 , Anatoliy N Alekseenko  5 , Yurii Pustovit  5 , Oleksandr Kiriakov  1 , Igor I Gerus  2 , Andrei A Tolmachev  1   4 , Pavel K Mykhailiuk  1   4
Affiliations

Deoxofluorination of (Hetero)aromatic Acids

Serhii Trofymchuk et al. J Org Chem. .

Abstract

Diverse trifluoromethyl-substituted compounds were synthesized by deoxofluorination of cinnamic and (hetero)aromatic carboxylic acids with sulfur tetrafluoride. The obtained products were used as starting materials in the preparation of novel fluorinated amino acids, anilines, and aliphatic amines - valuable building blocks for medicinal chemistry and agrochemistry.

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