Basophilia of the peripheral blood in patients with ulcerative colitis

Abstract

Background: Basophilia of the peripheral blood (PBB) has rarely been described in patients with ulcerative colitis (UC).Objective: This study aimed to determine the frequency of PBB in patients with UC and to examine a potential correlation of PBB with markers of inflammation.Methods: We compared retrospectively the basophil counts and the occurrence of basophilia (>200 basophils/µL) between 165 patients with UC and 35 controls, and analysed the correlation between the basophil count and the C-reactive protein (CRP).Results: Within the study period, data from 1750 leukocyte differential count determinations of UC patients and 158 results from control subjects were available in the medical records and were statistically analysed. The differences in the basophil counts between the UC and the control group were not statistically significant (60/µL (0-351) vs. 49/µL (0-184), p = .26). Basophilia was apparent in 23 measurements of 10 patients with UC, but was not observed in the controls (p = .30). The basophil count was not significantly correlated with the CRP (p = .065, r = 0.04).Conclusions: Our findings suggest that PBB represents an uncommon and not disease-specific laboratory feature of UC. It is not correlated with the CRP and may not represent a useful biomarker for disease monitoring in UC.

Keywords: Ulcerative colitis; basophilia; basophils; inflammatory bowel disease.