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Comment
. 2020 Feb 3;130(2):601-603.
doi: 10.1172/JCI134031.

Preclinical evaluation of patient-derived cells shows promise for Parkinson's disease

Jun Takahashi
Comment

Preclinical evaluation of patient-derived cells shows promise for Parkinson's disease

Jun Takahashi. J Clin Invest. .

Abstract

Parkinson's disease (PD) is a neurodegenerative disease caused by the progressive loss of dopaminergic (DA) neurons in the midbrain projecting to the striatum, which leads to motor dysfunctions, such as bradykinesia (slowed movement), rigidity, and tremors. To replace the lost cells, the transplantation of DA neurons derived from embryonic stem cells or induced pluripotent stem cells (iPSCs) has been considered. In this issue of the JCI, Song et al. report on their development of an iPSC induction and differentiation protocol that can promote the realization of autologous transplantation to treat PD patients with their own cells.

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Conflict of interest statement

Conflict of interest: JT receives research support from Sumitomo Dainippon Pharma.

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References

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