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. 2020 Jan-Mar;66(1):23-27.
doi: 10.4103/jpgm.JPGM_499_19.

A cross-sectional study of alexithymia in patients with relapse remitting form of multiple sclerosis

J Stojanov  1 , A Stojanov  2
Affiliations

A cross-sectional study of alexithymia in patients with relapse remitting form of multiple sclerosis

J Stojanov et al. J Postgrad Med. 2020 Jan-Mar.

Abstract

Background: Alexithymia is one's incapacity to identify, comprehend, and describe emotions. There is almost no literature data about the levels of alexithymia among patients with relapse remitting type of multiple sclerosis.

Aim: The objective of the present study was to assess the levels of alexithymia in patients with relapse remitting type of multiple sclerosis in relation to their sociodemographic variables and clinical characteristics of the disease.

Methods: This cross-sectional study included 106 consecutively assessed patients with relapse remitting type of multiple sclerosis. In addition to the data regarding disease duration, number of demyelinating relapses, and degree of neurological disability, assessed by the expanded disability scale score (EDSS), we used Toronto alexithymia scale (TAS), fatigue severity scale (FSS) and, Hamilton scale for the assessment of anxiety and depression and sociodemographic questionnaire.

Results: Study included 74 female and 32 male patients, with a median age of 44 years, median disease duration 90 months, and median EDSS 4. About 29.55% of patients had alexithymia and borderline alexithymia was observed in 31.15% patients. Alexithymia correlated with anxiety and depression (P < 0.01) on all TAS subscales. Higher levels of neurological disability based on EDSS, severe fatigue based on FSS scores, and severe relapse remitting type of multiple sclerosis with more relapses and longer disease duration correlated with alexithymia (P < 0.01), depression (P < 0.01), and anxiety (P < 0.01). Higher rates of alexithymia were noticed in older, unemployed, single patients, and those having fewer children.

Conclusions: Alexithymia was found in a relatively high percentage in patients with relapse remitting type of multiple sclerosis.

Keywords: Alexithymia; anxiety; depression; multiple sclerosis.

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Conflict of interest statement

None

References

    1. Moghaddam VK, Sarmadi M, Tatari M, Najafi F, Esmaeili A, Hadei M. Epidemiology of multiple sclerosis in Torbat-e Heydarieh (Northeast of Iran) during 1982-2016. Mult Scler Relat Disord. 2018;24:184–9. - PubMed
    1. Howard J, Trevick S, Younger DS. Epidemiology of multiple sclerosis. Neurol Clin. 2016;34:919–39. - PubMed
    1. Wallin MT, Culpepper WJ, Nichols E, Bhutta ZA, Gebrehiwot TT, Hay SI, et al. Global, regional, and national burden of multiple sclerosis 1990-2016: A systematic analysis for the Global Burden of Disease Study 2016. Lancet Neurol. 2019;18:269–85. - PMC - PubMed
    1. Inojosa H, Proschmann U, Akgün K, Ziemssen T. A focus on secondary progressive multiple sclerosis (SPMS): Challenges in diagnosis and definition. J Neurol. 2019 Jul 30; doi: 10.1007/s00415-019-09489-5. [Epub ahead of print] - PubMed
    1. Raimo S, Trojano L, Pappacena S, Alaia R, Spitaleri D, Grossi D, et al. Neuropsychological correlates of theory of mind deficits in patients with multiple sclerosis. Neuropsychology. 2017;31:811–21. - PubMed