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Review
. 2019 Dec 20:2019:8067045.
doi: 10.1155/2019/8067045. eCollection 2019.

Oxidative Stress-Related Endothelial Damage in Vascular Depression and Vascular Cognitive Impairment: Beneficial Effects of Aerobic Physical Exercise

Maria Luca  1 , Antonina Luca  1
Affiliations
Review

Oxidative Stress-Related Endothelial Damage in Vascular Depression and Vascular Cognitive Impairment: Beneficial Effects of Aerobic Physical Exercise

Maria Luca et al. Oxid Med Cell Longev. .

Abstract

Oxidative stress- (OS-) related endothelial damage is involved in the occurrence and progression of several disorders, such as vascular depression and dementia. It has been reported that moderate, aerobic, physical exercise could reduce OS and inflammation, thus limiting the cardiovascular risk factors while improving endothelial homeostasis, mood, and cognition. In this review, we will discuss about the role of OS and OS-related endothelial damage in vascular depression and vascular cognitive impairment. Then, we will comment on the effects of physical exercise on both disorders.

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Conflict of interest statement

The authors declare that there is no conflict of interests regarding the publication of this paper.

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References

    1. Bae Y. S., Oh H., Rhee S. G., Yoo Y. D. Regulation of reactive oxygen species generation in cell signaling. Molecules and Cells. 2011;32(6):491–509. doi: 10.1007/s10059-011-0276-3. - DOI - PMC - PubMed
    1. Dröge W. Free radicals in the physiological control of cell function. Physiological Reviews. 2002;82(1):47–95. doi: 10.1152/physrev.00018.2001. - DOI - PubMed
    1. Massaad C. A., Klann E. Reactive oxygen species in the regulation of synaptic plasticity and memory. Antioxidants & Redox Signaling. 2011;14(10):2013–2054. doi: 10.1089/ars.2010.3208. - DOI - PMC - PubMed
    1. Brown D. I., Griendling K. K. Nox proteins in signal transduction. Free Radical Biology & Medicine. 2009;47(9):1239–1253. doi: 10.1016/j.freeradbiomed.2009.07.023. - DOI - PMC - PubMed
    1. Chiang P. L., Chen H. L., Lu C. H., et al. Interaction of systemic oxidative stress and mesial temporal network degeneration in Parkinson's disease with and without cognitive impairment. Journal of Neuroinflammation. 2018;15(1) doi: 10.1186/s12974-018-1317-z. - DOI - PMC - PubMed