Can stem cell therapy increase the rate of myocardial recovery in left ventricular assist device-supported advanced heart failure patients?-current data and future perspectives

Gregor Poglajen^{1

2}, Bojan Vrtovec^{1

2}

Affiliations

¹ Advanced Heart Failure and Transplantation Center, Department of Cardiology, University Medical Center Ljubljana, Slovenia.
² Medical Faculty, University of Ljubljana, Slovenia.

Editorial

Gregor Poglajen et al. Ann Transl Med. 2019 Nov.

. 2019 Nov;7(22):613.

doi: 10.21037/atm.2019.10.60.

Gregor Poglajen^{1

2}, Bojan Vrtovec^{1

2}

¹ Advanced Heart Failure and Transplantation Center, Department of Cardiology, University Medical Center Ljubljana, Slovenia.
² Medical Faculty, University of Ljubljana, Slovenia.

No abstract available

Conflict of interest statement

Conflicts of Interest: The authors have no conflicts of interest to declare.

Intramyocardial Injection of Mesenchymal Precursor Cells and Successful Temporary Weaning From Left Ventricular Assist Device Support in Patients With Advanced Heart Failure: A Randomized Clinical Trial.
Yau TM, Pagani FD, Mancini DM, Chang HL, Lala A, Woo YJ, Acker MA, Selzman CH, Soltesz EG, Kern JA, Maltais S, Charbonneau E, Pan S, Marks ME, Moquete EG, O'Sullivan KL, Taddei-Peters WC, McGowan LK, Green C, Rose EA, Jeffries N, Parides MK, Weisel RD, Miller MA, Hung J, O'Gara PT, Moskowitz AJ, Gelijns AC, Bagiella E, Milano CA; Cardiothoracic Surgical Trials Network. Yau TM, et al. JAMA. 2019 Mar 26;321(12):1176-1186. doi: 10.1001/jama.2019.2341. JAMA. 2019. PMID: 30912838 Free PMC article. Clinical Trial.

1. Benjamin EJ, Blaha MJ, Chiuve SE, et al. Heart Disease and Stroke Statistics-2017 Update: A Report From the American Heart Association. Circulation 2017;135:e146-603. 10.1161/CIR.0000000000000485 - DOI - PMC - PubMed
1. Mann DL, Barger PM, Burkhoff D. Myocardial recovery and the failing heart: myth, magic, or molecular target? J Am Coll Cardiol 2012;60:2465-72. 10.1016/j.jacc.2012.06.062 - DOI - PMC - PubMed
1. Topkara VK, Garan AR, Fine B, et al. Myocardial Recovery in Patients Receiving Contemporary Left Ventricular Assist Devices: Results From the Interagency Registry for Mechanically Assisted Circulatory Support (INTERMACS). Circ Heart Fail 2016. doi: .10.1161/CIRCHEARTFAILURE.116.003157 - DOI - PMC - PubMed
1. Poglajen G, Vrtovec B. Stem cell therapy for chronic heart failure. Curr Opin Cardiol 2015;30:301-10. 10.1097/HCO.0000000000000167 - DOI - PubMed
1. Vrtovec B. Cell Therapy for Nonischemic Cardiomyopathy: Current Status and Future Perspectives. Circ Res 2018;122:28-30. 10.1161/CIRCRESAHA.117.312385 - DOI - PubMed