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. 2019 Nov;7(22):636.
doi: 10.21037/atm.2019.10.110.

Hyperuricemia and long-term mortality in patients with acute myocardial infarction undergoing percutaneous coronary intervention

Wei Guo  1   2 , Dahao Yang  3 , Dengxuan Wu  4 , Huixia Liu  1 , Shiqun Chen  2 , Jin Liu  2 , Li Lei  2 , Yong Liu  2 , Lifen Rao  1 , Li Zhang  1 ; RESCIND Group
Affiliations

Hyperuricemia and long-term mortality in patients with acute myocardial infarction undergoing percutaneous coronary intervention

Wei Guo et al. Ann Transl Med. 2019 Nov.

Abstract

Background: Although serum uric acid (UA) was regarded to be involved in cardiovascular disease, the role of serum UA (SUA) as a risk factor in acute myocardial infarction (AMI) is controversial. We investigated whether hyperuricemia was linked with long-term mortality in patients with AMI who underwent percutaneous coronary intervention (PCI).

Methods: Patients with AMI who received PCI were consecutively included. The definition of preprocedural hyperuricemia was a SUA level >7 mg/dL (417 mmol/L) in males and >6 mg/dL (357 mmol/L) in females. All-cause mortality was assessed during 2.3-year median follow up period.

Results: One thousand and five patients with AMI undergoing PCI were enrolled in a single center study, 307 (30.5%) patients had hyperuricemia. After adjusting for potential confounding factors, the multivariable analysis indicated that preprocedural hyperuricemia was related to an increased risk of all-cause mortality during the 2.3-year follow-up (HR: 1.97; 95% CI: 1.11-3.49; P=0.019).

Conclusions: Preprocedural hyperuricemia, independently from chronic kidney disease (CKD), is a significant and independent predictor of long-term mortality for patients with AMI who underwent PCI.

Keywords: Uric acid (UA); acute myocardial infarction (AMI); percutaneous coronary intervention (PCI).

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Conflict of interest statement

Conflicts of Interest: The authors have no conflicts of interest to declare.

Figures

Figure 1
Figure 1
Kaplan-Meier estimates of mortality according to hyperuricemia. The incidence of mortality was increased in the hyperuricemic group.
See this image and copyright information in PMC

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