Modeling neurological disease using human stem cell-derived microglia-like cells transplanted into rodent brains

Fadi Jacob^{1

2

3}, Mariko L Bennett⁴

Affiliations

¹ The Solomon H. Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD, 21205, USA. fjacob2@jhmi.edu.
² Medical Scientist Training Program, Johns Hopkins University School of Medicine, Baltimore, MD, 21205, USA. fjacob2@jhmi.edu.
³ Department of Neuroscience and Mahoney Institute for Neurosciences, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA. fjacob2@jhmi.edu.
⁴ Department of Pediatrics, Children's Hospital of Philadelphia, Philadelphia, PA, 19104, USA.

Comment

Fadi Jacob et al. Lab Anim (NY). 2020 Feb.

. 2020 Feb;49(2):49-51.

doi: 10.1038/s41684-019-0465-9.

Fadi Jacob^{1

2

3}, Mariko L Bennett⁴

¹ The Solomon H. Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD, 21205, USA. fjacob2@jhmi.edu.
² Medical Scientist Training Program, Johns Hopkins University School of Medicine, Baltimore, MD, 21205, USA. fjacob2@jhmi.edu.
³ Department of Neuroscience and Mahoney Institute for Neurosciences, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA. fjacob2@jhmi.edu.
⁴ Department of Pediatrics, Children's Hospital of Philadelphia, Philadelphia, PA, 19104, USA.

No abstract available

Comment on

Development of a Chimeric Model to Study and Manipulate Human Microglia In Vivo.
Hasselmann J, Coburn MA, England W, Figueroa Velez DX, Kiani Shabestari S, Tu CH, McQuade A, Kolahdouzan M, Echeverria K, Claes C, Nakayama T, Azevedo R, Coufal NG, Han CZ, Cummings BJ, Davtyan H, Glass CK, Healy LM, Gandhi SP, Spitale RC, Blurton-Jones M. Hasselmann J, et al. Neuron. 2019 Sep 25;103(6):1016-1033.e10. doi: 10.1016/j.neuron.2019.07.002. Epub 2019 Jul 30. Neuron. 2019. PMID: 31375314 Free PMC article.
Stem-cell-derived human microglia transplanted in mouse brain to study human disease.
Mancuso R, Van Den Daele J, Fattorelli N, Wolfs L, Balusu S, Burton O, Liston A, Sierksma A, Fourne Y, Poovathingal S, Arranz-Mendiguren A, Sala Frigerio C, Claes C, Serneels L, Theys T, Perry VH, Verfaillie C, Fiers M, De Strooper B. Mancuso R, et al. Nat Neurosci. 2019 Dec;22(12):2111-2116. doi: 10.1038/s41593-019-0525-x. Epub 2019 Oct 28. Nat Neurosci. 2019. PMID: 31659342 Free PMC article.

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