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Comment
. 2020 Feb;21(2):104-105.
doi: 10.1038/s41590-019-0579-7.

Of larks and owls

Mariana J Kaplan  1
Affiliations
Comment

Of larks and owls

Mariana J Kaplan. Nat Immunol. 2020 Feb.
No abstract available

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Figures

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In mice, neutrophils freshly released from the bone marrow in the late night/early morning display a higher protein content stored in their granules and enhanced ability to form NETs. As they travel through the circulation during the day, neutrophils gradually modulate their proteome through controlled degranulation and decrease their ability to form NETs. Once they exit into tissues such as the lungs, the toxic arsenal of the neutrophils is significantly decreased and they are less capable of forming NETs and damaging tissues. These changes in the neutrophil proteome determine variations in organ damage depending on the time of day, following the circadian rhythm.
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Comment on

  • Programmed 'disarming' of the neutrophil proteome reduces the magnitude of inflammation.
    Adrover JM, Aroca-Crevillén A, Crainiciuc G, Ostos F, Rojas-Vega Y, Rubio-Ponce A, Cilloniz C, Bonzón-Kulichenko E, Calvo E, Rico D, Moro MA, Weber C, Lizasoaín I, Torres A, Ruiz-Cabello J, Vázquez J, Hidalgo A. Adrover JM, et al. Nat Immunol. 2020 Feb;21(2):135-144. doi: 10.1038/s41590-019-0571-2. Epub 2020 Jan 13. Nat Immunol. 2020. PMID: 31932813 Free PMC article.

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