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. 2019 Sep 1;12(9):3390-3398.
eCollection 2019.

Clinicopathological significances of Feline sarcoma-related protein and β2-adrenoceptor expression in pancreatic ductal adenocarcinomas

Xin Luo  1 , Zhulin Yang  2 , Xiao Liu  2 , Ziru Liu  2 , Xiongying Miao  2 , Daiqiang Li  1 , Qiong Zou  3 , Yuan Yuan  3
Affiliations

Clinicopathological significances of Feline sarcoma-related protein and β2-adrenoceptor expression in pancreatic ductal adenocarcinomas

Xin Luo et al. Int J Clin Exp Pathol. .

Abstract

Introduction: Pancreatic ductal adenocarcinoma (PDAC) is a highly malignant tumor with a high mortality, but biomarkers for its diagnosis, target therapy, and prognosis are not clinically available.

Materials and methods: In the present study, Feline sarcoma-related protein (Fer) and ADRB2 protein expression was detected by immunohistochemistry.

Results and discussion: Comparing with the peritumoral tissues, benign pancreatic tissues, and normal pancreatic tissues, Fer and ADRB2 protein was overexpressed in PDAC tumor tissues (P < 0.01). The percentage of patients with positive Fer and ADRB2 expression were significantly lower in PDAC without lymph node metastasis, without invasion to surrounding tissues and organs, and with low TNM stage (I/II stage) disease compared to PDAC patients with metastasis, invasion, and high TNM stage (III/IV) disease. PDAC patients with positive Fer or ADRB2 protein expression survived significantly shorter time than patients with negative Fer or ADRB2 protein expression (P = 0.000). Positive Fer and ADRB2 protein expression was an independent factor for poor prognosis of PDAC patients and ROC curve analysis showed that positive Fer and ADRB2 protein expression was sensitive and specific marker for the PDAC diagnosis. In conclusion, positive Fer and ADRB2 expression is associated with carcinogenesis of PDAC, disease progression, and poor prognosis of PDAC patients.

Keywords: ADRB2; Fer; PDAC; immunohistochemistry; pancreatic tissue.

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Conflict of interest statement

None.

Figures

Figure 1
Figure 1
Immunohistological staining of Fer protein. A. Positive expression of Fer in poorly differentiated PDAC, ×200. B. Negative expression of Fer in poorly differentiated PDAC, ×200. C. Positive expression of Fer in chronic pancreatitis, ×200. D. Positive expression of Fer in adenoma, ×200.
Figure 2
Figure 2
Immunohistological staining of ADRB2 protein. A. Positive expression of ADRB2 in moderately-differentiated PDAC, ×200. B. Negative expression of ADRB2 in poorly differentiated PDAC, ×200. C. Positive expression of ADRB2 in intraepithelial neoplasia II, ×200. D. Positive expression of ADRB2 in peritumori tissue, ×200.
Figure 3
Figure 3
Kaplan-Meier plots of overall survival and receiver operating characteristic curve analysis. A. Kaplan-Meier plots of overall survival in patients with PDAC and with positive and negative Fer expression. B. Kaplan-Meier plots of overall survival in patients with PDAC and with positive and negative ADRB2 expression. C. ROC analysis of the diagnosis ability of Fer. D. ROC analysis of the diagnosis ability of ADRB2.
See this image and copyright information in PMC

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