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. 2020 Mar;27(3):263-268.
doi: 10.1097/GME.0000000000001477.

Interaction between postmenopausal hormone therapy and diabetes on cataract

Christy Costanian  1   2 , Marie-Josée Aubin  3   4 , Ralf Buhrmann  5 , Ellen E Freeman  1   3   4   5
Affiliations

Interaction between postmenopausal hormone therapy and diabetes on cataract

Christy Costanian et al. Menopause. 2020 Mar.

Abstract

Objective: We investigated whether postmenopausal hormone therapy (HT) use interacts with diabetes, a risk factor for several age-related eye diseases.

Methods: A cross-sectional analysis of women involved in the Canadian Longitudinal Study on Aging was performed. The random sample comprised of 15,320 community-dwelling women between ages 45 and 85 years old sampled from areas adjacent to 11 data collection centers across Canada. Information on menopausal status and HT were collected by self-report. Data on diabetes and eye disease were obtained by self-report of a physician diagnosis. Multivariable logistic regression was used.

Results: After adjusting for demographic, lifestyle, and health variables, a multiplicative interaction was identified such that HT use for 10 years or more was associated with a much higher odds of a report of cataract in women with type 2 diabetes (odds ratio = 2.44, 95% confidence interval 1.49, 3.99) but not in long-term HT users with no diabetes (odds ratio = 1.03, 95% confidence interval 0.87, 1.21) (interaction term P value = 0.013). HT use was not associated with glaucoma or macular degeneration.

Conclusions: Long-term HT use and type 2 diabetes interact in their relationship with cataract. This novel finding should be confirmed. If confirmed, women with type 2 diabetes should be informed that long-term HT use increases their risk of cataract. : Video Summary:http://links.lww.com/MENO/A519.

Plain language summary

Video Summary:http://links.lww.com/MENO/A519.

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Conflict of interest statement

Financial disclosure/conflicts of interest: None reported.

Figures

FIG. 1
FIG. 1
Interaction between hormone therapy duration and type 2 diabetes in their relationship with report of cataract. Long-term hormone therapy users with type 2 diabetes have a much higher odds of cataract. HT, hormone therapy.
See this image and copyright information in PMC

Comment in

References

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