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Review
. 2019;119(10. Vyp. 2):14-20.
doi: 10.17116/jnevro201911910214.

[Pathological and protective effects of tumor necrosis factor-alpha in multiple sclerosis]

[Article in Russian]
I V Smagina  1 , S A Elchaninova  2 , A S Palashchenko  1 , L P Galaktionova  2
Affiliations
Review

[Pathological and protective effects of tumor necrosis factor-alpha in multiple sclerosis]

[Article in Russian]
I V Smagina et al. Zh Nevrol Psikhiatr Im S S Korsakova. 2019.

Abstract
in English, Russian

The immunomodulatory cytokine tumor necrosis factor-alpha (TNF-α) is involved in the regulation of both physiological and pathological processes in the central nervous system (CNS). The effects of TNF-α on CNS reported in clinical trials and experimental studies, evidence of involvement of this cytokine in the pathogenesis of multiple sclerosis are analyzed. Possible causes of failures of non-selective pharmacological inhibition of TNF-α effects in MS are considered in view of current concepts on mechanisms of TNF-α action.

Иммуномодулирующий цитокин - фактор некроза опухоли-альфа (TNF-α) участвует в регуляции как физиологических, так и патологических процессов в ЦНС. В обзоре анализируются данные об эффектах TNF-α в ЦНС, полученные в клинических наблюдениях и экспериментальных исследованиях, доказательства вовлеченности этого цитокина в патогенез РС. В свете современных представлений о механизмах действия TNF-α рассматриваются возможные причины неудач неселективного фармакологического подавления эффектов TNF-α при РС.

Keywords: central nervous system; multiple sclerosis; tumor necrosis factor-alpha; tumor necrosis factor-alpha receptors.

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