Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2020 Jan 8;21(2):393.
doi: 10.3390/ijms21020393.

New Nanotechnologies for the Treatment and Repair of Skin Burns Infections

Eliana B Souto  1   2 , André F Ribeiro  1 , Maria I Ferreira  1 , Maria C Teixeira  1 , Andrea A M Shimojo  1   3 , José L Soriano  4 , Beatriz C Naveros  4 , Alessandra Durazzo  5 , Massimo Lucarini  5 , Selma B Souto  6 , Antonello Santini  7
Affiliations
Review

New Nanotechnologies for the Treatment and Repair of Skin Burns Infections

Eliana B Souto et al. Int J Mol Sci. .

Abstract

Burn wounds are highly debilitating injuries, with significant morbidity and mortality rates worldwide. In association with the damage of the skin integrity, the risk of infection is increased, posing an obstacle to healing and potentially leading to sepsis. Another limitation against healing is associated with antibiotic resistance mainly due to the use of systemic antibiotics for the treatment of localized infections. Nanotechnology has been successful in finding strategies to incorporate antibiotics in nanoparticles for the treatment of local wounds, thereby avoiding the systemic exposure to the drug. This review focuses on the most recent advances on the use of nanoparticles in wound dressing formulations and in tissue engineering for the treatment of burn wound infections.

Keywords: antibiotics; burn wound infection; nanoparticles; wound healing.

PubMed Disclaimer

Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Different degrees of burn wounds and affected skin layers.
See this image and copyright information in PMC

References

    1. Mofazzal Jahromi M.A., Sahandi Zangabad P., Moosavi Basri S.M., Sahandi Zangabad K., Ghamarypour A., Aref A.R., Karimi M., Hamblin M.R. Nanomedicine and advanced technologies for burns: Preventing infection and facilitating wound healing. Adv. Drug Deliv. Rev. 2018;123:33–64. doi: 10.1016/j.addr.2017.08.001. - DOI - PMC - PubMed
    1. Douglas H.E., Dunne J.A., Rawlins J.M. Management of burns. Surgery. 2017;35:511–518. doi: 10.1016/j.mpsur.2017.06.007. - DOI
    1. Sanchez D.A., Schairer D., Tuckman-Vernon C., Chouake J., Kutner A., Makdisi J., Friedman J.M., Nosanchuk J.D., Friedman A.J. Amphotericin B releasing nanoparticle topical treatment of Candida spp. in the setting of a burn wound. Nanomedicine. 2014;10:269–277. doi: 10.1016/j.nano.2013.06.002. - DOI - PubMed
    1. World Health Organization Burns—Key Facts. [(accessed on 4 January 2020)]; Available online: https://www.who.int/news-room/fact-sheets/detail/burns.
    1. Santos J.V., Oliveira A., Costa-Pereira A., Amarante J., Freitas A. Burden of burns in Portugal, 2000-2013: A clinical and economic analysis of 26,447 hospitalisations. Burns. 2016;42:891–900. doi: 10.1016/j.burns.2016.01.017. - DOI - PubMed

Substances