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. 2020 Jan 10;10(1):115.
doi: 10.3390/ani10010115.

Can Enterocin M in Combination with Sage Extract Have Beneficial Effect on Microbiota, Blood Biochemistry, Phagocytic Activity and Jejunal Morphometry in Broiler Rabbits?

Monika Pogány Simonová  1 , Ľubica Chrastinová  2 , Anna Kandričáková  1 , Soňa Gancarčíková  3 , Eva Bino  1 , Iveta Plachá  1 , Jana Ščerbová  1 , Viola Strompfová  1 , Rudolf Žitňan  2 , Andrea Lauková  1
Affiliations

Can Enterocin M in Combination with Sage Extract Have Beneficial Effect on Microbiota, Blood Biochemistry, Phagocytic Activity and Jejunal Morphometry in Broiler Rabbits?

Monika Pogány Simonová et al. Animals (Basel). .

Abstract

The present study investigated the effects of enterocin (Ent) M and sage extract alone and also in combination on the gut microflora, phagocytic activity, blood biochemistry, and morphometry of rabbits. Sixty-four rabbits (aged five weeks, M91 meatline, both sexes) were divided into three experimental groups: E (EntM; 50 µL/animal/day), S (sage; 10 µL/animal/day), and E + S (EntM + sage) groups and control group (C). The additives were administered in drinking water for a period of 21 days. Dietary supplementation of EntM and sage significantly reduced the coliforms (E: p < 0.001; S: p < 0.001; E + S: p < 0.001) in feces, while simultaneous addition of EntM and sage decreased enterococci (E + S: p < 0.0001), lactic acid bacteria (E + S: p < 0.01), and coagulase-positive staphylococci (E + S: p < 0.0001) in the appendix. Sage addition reduced HDL (S: p < 0.001) and LDL cholesterol (S: p < 0.001; E + S: p < 0.001), LDL/HDL ratio (S: p < 0.001; E + S: p < 0.01), and increased urea (S: p < 0.01; E + S: p < 0.001) and creatinine (S: p < 0.001; E + S: p < 0.001) in serum. EntM and sage application, alone or in combination, improve the jejunal morphometry (p < 0.0001) in rabbits.

Keywords: enterocin; microbiota; morphometry; phagocytic activity; rabbit; sage.

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Conflict of interest statement

The authors declare no conflict of interest. The funders had no role in the design of the study; in the collection, analyses, or interpretation of data; in the writing of the manuscript, or in the decision to publish the results.

References

    1. Dalle Zotte A., Celia C., Szendrő Z. Herbs and spices inclusion as feedstuff or additive in growing rabbit diet and as additive in rabbit meat: A review. Livest. Sci. 2016;189:82–90. doi: 10.1016/j.livsci.2016.04.024. - DOI
    1. Falcão-e-Cunha L., Castro-Solla L., Maertens L., Marounek M., Pinheiro V., Freire J., Mourão J.L. Alternatives to antibiotic growth promoters in rabbit feeding: A review. World Rabbit Sci. 2007;15:127–140. doi: 10.4995/wrs.2007.597. - DOI
    1. Kritas S.K., Petridou E.I., Fortomaris P., Tzika E., Arsenos G., Koptopoulos G. The effect of probiotics on microbiology, health and performance of fattening rabbits. Asian Australas. J. Anim. Sci. 2008;21:1312–1317. doi: 10.5713/ajas.2008.70186. - DOI
    1. Pogány Simonová M., Lauková A., Chrastinová Ľ., Strompfová V., Faix Š., Vasilková Z., Ondruška Ľ., Jurčík R., Rafay J. Enterococcus faecium CCM7420, bacteriocin PPB CCM7420 and their effect in thedigestive tract of rabbits. Czech J. Anim. Sci. 2009;54:376–386. doi: 10.17221/1659-CJAS. - DOI
    1. Bhatt R.S., Agrawal A.R., Sahoo A. Effect of probiotic supplementation on growth performance, nutrientutilization and carcass characteristics of growing Chinchilla rabbits. J. Appl. Anim. Res. 2017;45:304–309. doi: 10.1080/09712119.2016.1174126. - DOI