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Review
. 2020 Aug;22(8):1240-1251.
doi: 10.1007/s12094-019-02276-8. Epub 2020 Jan 14.

Organoid of ovarian cancer: genomic analysis and drug screening

H-D Liu  1 , B-R Xia  1 , M-Z Jin  2 , G Lou  3
Affiliations
Review

Organoid of ovarian cancer: genomic analysis and drug screening

H-D Liu et al. Clin Transl Oncol. 2020 Aug.

Abstract

Ovarian cancer is the most common malignant tumors of the female reproductive system, and its standard treatments are cytoreductive surgery and platinum-based adjuvant chemotherapy. Great advances have been achieved in novel treatment strategies, including targeted therapy and immunotherapy. However, ovarian cancer has the highest mortality rate among gynecological tumors due to therapeutic resistance and the gap between preclinical data and actual clinical efficacy. Organoids are a 3D culture model that markedly affects gene analysis, drug screening, and drug sensitivity determination of tumors, especially when used in targeted therapy and immunotherapy. In addition, organoid can lead to advances in the preclinical research of ovarian cancer due to its convenient cultivation, good genetic stability, and high homology with primary tumors.

Keywords: Drug screening; Immunotherapy; Organoid; Ovarian cancer; Targeted therapy.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that may be construed as a potential conflict of interest.

Figures

Fig. 1
Fig. 1
Simple organoid culture
Fig. 2
Fig. 2
The Sketch of organoid application
See this image and copyright information in PMC

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