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Review
. 2020 Jun;121(5-6):3235-3247.
doi: 10.1002/jcb.29591. Epub 2020 Jan 14.

Emerging roles of HOTAIR in human cancer

Chunjue Yuan  1   2 , Yong Ning  2 , Yunbao Pan  1   3
Affiliations
Review

Emerging roles of HOTAIR in human cancer

Chunjue Yuan et al. J Cell Biochem. 2020 Jun.

Abstract

Long noncoding RNA HOX antisense intergenic RNA (HOTAIR) is overexpressed in many types of cancers, and substantial evidence has suggested a link between cancers and HOTAIR. In the present study, we reviewed the structure and the corresponding biologic function of HOTAIR to clarify its molecular mechanism in cancer progression. HOTAIR promotes proliferation, invasion, and migration, and inhibits apoptosis in cancer cells. HOTAIR also participates in the pathogenesis and progression of cancer by regulating inflammation and immune signaling. These findings suggested that HOTAIR is a novel biomarker in human cancers.

Keywords: HOTAIR; biomarker; epithelial-mesenchymal transformation; immune signaling; nasopharyngeal carcinoma.

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