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Review
. 2020 May 15;26(28):6102-6112.
doi: 10.1002/chem.201905506. Epub 2020 Mar 19.

Ruthenium-Induced Cyclization of Heteroatom-Functionalized Alkynes: Progress, Challenges and Perspectives

Lai-Hon Chung  1 , Chi-Fung Yeung  1   2 , Chun-Yuen Wong  1   2
Affiliations
Review

Ruthenium-Induced Cyclization of Heteroatom-Functionalized Alkynes: Progress, Challenges and Perspectives

Lai-Hon Chung et al. Chemistry. .

Abstract

Metal-induced cyclization of functionalized alkynes represents one of the most general approaches to prepare organic heterocycles. Although RuII centers are well-established to promote alkyne to vinylidene rearrangements and many RuII -mediated alkyne cyclizations have been rationalized to be the results of post-vinylidene transformations, recent discoveries indicate that RuII centers can serve as electrophiles and induce alkyne cyclizations without vinylidene intermediacy. In this Minireview, an overview of the RuII -induced cyclization of heteroatom-functionalized alkynes in the last decade is provided, with an emphasis on the discoveries and validations of the unconventional "non-vinylidene-involving" pathways.

Keywords: alkynes; cyclization; reaction mechanisms; ruthenium; vinylidene.

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