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Review
. 2020 Jan;26(1):47-54.
doi: 10.1111/tbj.13724. Epub 2020 Jan 15.

Hypofractionated radiation treatment for breast cancer: The time is now

Meena S Moran  1 , Pauline T Truong  2
Affiliations
Review

Hypofractionated radiation treatment for breast cancer: The time is now

Meena S Moran et al. Breast J. 2020 Jan.

Abstract

While there is now Level I data with long-term follow-up supporting the routine use of hypofractionated (HF) whole-breast radiation therapy (WBRT) after breast-conserving surgery, its adoption has been slow and variable. This article will review the literature supporting the efficacy and safety of hypofractionated radiation for breast cancer, discuss the radiobiological rationale specific to breast tumors, and make an argument for justifying the routine adoption of shorter, HF-WBRT courses when delivering breast radiation. Data using HF with regional nodal irradiation and in the post-mastectomy setting will also be reviewed. The aim is to provide an in-depth understanding of the use of hypofractionated radiation therapy for breast cancer, its applicability, and topics warranting future research.

Keywords: breast cancer; conventional fractionation; hypofractionation; radiation therapy; radiobiology.

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References

REFERENCES

    1. Veronesi U, Cascinelli N, Mariani L, et al. Twenty-year follow-up of a randomized study comparing breast-conserving surgery with radical mastectomy for early breast cancer. N Engl J Med. 2002;347(16):1227-1232.
    1. Fisher B, Anderson S, Bryant J, et al. Twenty-year follow-up of a randomized trial comparing total mastectomy, lumpectomy, and lumpectomy plus irradiation for the treatment of invasive breast cancer. N Engl J Med. 2002;347(16):1233-1241.
    1. Blichert-Toft M, Nielsen M, Düring M, et al. Long-term results of breast conserving surgery vs. mastectomy for early stage invasive breast cancer: 20-year follow-up of the Danish randomized DBCG-82TM protocol. Acta Oncol. 2008;47(4):672-681.
    1. Gianfaldoni S, Gianfaldoni R, Wollina U, Lotti J, Tchernev G, Lotti T. An overview on radiotherapy: from its history to its current applications in dermatology. Open Access Maced J Med Sci. 2017;5(4):521-525.
    1. Regaud CFR. Discordance des Effets de rayons X, d’une part dans le testicule, par le fractionnement de la dose. C R Soc Biol. 1927;97:431.

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