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. 1988 Nov 18;242(4881):1042-5.
doi: 10.1126/science.3194754.

Cloning of a membrane protein that induces a slow voltage-gated potassium current

T Takumi  1 , H Ohkubo, S Nakanishi
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Cloning of a membrane protein that induces a slow voltage-gated potassium current

T Takumi et al. Science. .

Abstract

A rat kidney messenger RNA that induces a slowly activating, voltage-dependent potassium current on its expression in Xenopus oocytes was identified by combining molecular cloning with an electrophysiological assay. The cloned complementary DNA encodes a novel membrane protein that consists of 130 amino acids with a single putative transmembrane domain. This protein differs from the known ion channel proteins but is involved in the induction of selective permeation of potassium ions by membrane depolarization.

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