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Review
. 2020 Jan 14;18(1):54.
doi: 10.3390/md18010054.

Recent Discovery of Heterocyclic Alkaloids from Marine-Derived Aspergillus Species

Kuo Xu  1 , Xiao-Long Yuan  1 , Chen Li  2   3 , And Xiao-Dong Li  2   3
Affiliations
Review

Recent Discovery of Heterocyclic Alkaloids from Marine-Derived Aspergillus Species

Kuo Xu et al. Mar Drugs. .

Abstract

Nitrogen heterocycles have drawn considerable attention due to of their significant biological activities. The marine fungi residing in extreme environments are among the richest sources of these basic nitrogen-containing secondary metabolites. As one of the most well-known universal groups of filamentous fungi, marine-derived Aspergillus species produce a large number of structurally unique heterocyclic alkaloids. This review attempts to provide a comprehensive summary of the structural diversity and biological activities of heterocyclic alkaloids that are produced by marine-derived Aspergillus species. Herein, a total of 130 such structures that were reported from the beginning of 2014 through the end of 2018 are included, and 75 references are cited in this review, which will benefit future drug development and innovation.

Keywords: Aspergillus; alkaloid; biological activity; marine; metabolite.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Indole alkaloids produced by marine-derived Aspergillus species (1–31).
Figure 2
Figure 2
Diketopiperazine alkaloids produced by marine-derived Aspergillus species (32–58).
Figure 3
Figure 3
Quinazoline alkaloids produced by marine-derived Aspergillus species (59–72).
Figure 4
Figure 4
Pyrrolidine alkaloids produced by marine-derived Aspergillus species (73–96).
Figure 5
Figure 5
Cyclic peptide alkaloids produced by marine-derived Aspergillus species (97–108).
Figure 6
Figure 6
Other alkaloids isolated from marine-derived Aspergillus species (109–130).
Figure 7
Figure 7
Anticancer heterocyclic alkaloids produced by marine-derived Aspergillus species.
Figure 8
Figure 8
Antimicrobial heterocyclic alkaloids that are produced by marine-derived Aspergillus species.
Figure 9
Figure 9
Anti-inflammatory heterocyclic alkaloids produced by marine-derived Aspergillus species.
Figure 10
Figure 10
Other bioactive heterocyclic alkaloids produced by marine-derived Aspergillus species.
See this image and copyright information in PMC

References

    1. Rida P.C., LiVecche D., Ogden A., Zhou J., Aneja R. The noscapine chronicle: A pharmaco-historic biography of the opiate alkaloid family and its clinical applications. Med. Res. Rev. 2015;35:1072–1096. doi: 10.1002/med.21357. - DOI - PMC - PubMed
    1. Pirillo A., Catapano A.L. Berberine, a plant alkaloid with lipid- and glucose-lowering properties: From in vitro evidence to clinical studies. Atherosclerosis. 2015;243:449–461. doi: 10.1016/j.atherosclerosis.2015.09.032. - DOI - PubMed
    1. Ferraz C.A.A., de Oliveira Júnior R.G., Picot L., da Silva Almeida J.R.G., Nunes X.P. Pre-clinical investigations of β-carboline alkaloids as antidepressant agents: A systematic review. Fitoterapia. 2019;137:104196. doi: 10.1016/j.fitote.2019.104196. - DOI - PubMed
    1. Wang B.G., Gloer J.B., Ji N.Y., Zhao J.C. Halogenated organic molecules of Rhodomelaceae origin: Chemistry and biology. Chem. Rev. 2013;113:3632–3685. doi: 10.1021/cr9002215. - DOI - PubMed
    1. Gogineni V., Schinazi R.F., Hamann M.T. Role of marine natural products in the genesis of antiviral agents. Chem. Rev. 2015;115:9655–9706. doi: 10.1021/cr4006318. - DOI - PMC - PubMed