Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2020 Jan 5;21(1):358.
doi: 10.3390/ijms21010358.

Oxidative Stress-Responsive MicroRNAs in Heart Injury

Branislav Kura  1 , Barbara Szeiffova Bacova  1 , Barbora Kalocayova  1 , Matus Sykora  1   2 , Jan Slezak  1
Affiliations
Review

Oxidative Stress-Responsive MicroRNAs in Heart Injury

Branislav Kura et al. Int J Mol Sci. .

Abstract

Reactive oxygen species (ROS) are important molecules in the living organisms as a part of many signaling pathways. However, if overproduced, they also play a significant role in the development of cardiovascular diseases, such as arrhythmia, cardiomyopathy, ischemia/reperfusion injury (e.g., myocardial infarction and heart transplantation), and heart failure. As a result of oxidative stress action, apoptosis, hypertrophy, and fibrosis may occur. MicroRNAs (miRNAs) represent important endogenous nucleotides that regulate many biological processes, including those involved in heart damage caused by oxidative stress. Oxidative stress can alter the expression level of many miRNAs. These changes in miRNA expression occur mainly via modulation of nuclear factor erythroid 2-related factor 2 (Nrf2), sirtuins, calcineurin/nuclear factor of activated T cell (NFAT), or nuclear factor kappa B (NF-κB) pathways. Up until now, several circulating miRNAs have been reported to be potential biomarkers of ROS-related cardiac diseases, including myocardial infarction, hypertrophy, ischemia/reperfusion, and heart failure, such as miRNA-499, miRNA-199, miRNA-21, miRNA-144, miRNA-208a, miRNA-34a, etc. On the other hand, a lot of studies are aimed at using miRNAs for therapeutic purposes. This review points to the need for studying the role of redox-sensitive miRNAs, to identify more effective biomarkers and develop better therapeutic targets for oxidative-stress-related heart diseases.

Keywords: cardiovascular diseases; ischemia/reperfusion injury; miRNA; oxidative stress; transplantation.

PubMed Disclaimer

Conflict of interest statement

The authors declare no conflicts of interest.

Figures

Figure 1
Figure 1
Impact of oxidative stress on the heart. Overproduction of reactive oxygen species (ROS) contributes to different cardiac pathologies, e.g., hypertrophy or fibrosis. These pathological changes in the heart may result in cardiovascular diseases, which may subsequently contribute to the production of ROS.
Figure 2
Figure 2
Selected signaling pathways (Nrf2, SIRT1, and NF-κB) influenced by miRNAs in situations with oxidative stress. ROS either inhibit or induce miRNA expression level. This leads to subsequent regulation of their target genes. Upper arrow represents increase of oxidative stress/activation of signaling pathway.
See this image and copyright information in PMC

References

    1. Roth G.A., Abate D., Abate K.H., Abay S.M., Abbafati C., Abbasi N., Abbastabar H., Abd-Allah F., Abdela J., Abdelalim A., et al. Global, regional, and national age-sex-specific mortality for 282 causes of death in 195 countries and territories, 1980–2017: A systematic analysis for the Global Burden of Disease Study 2017. Lancet. 2018;392:1736–1788. doi: 10.1016/S0140-6736(18)32203-7. - DOI - PMC - PubMed
    1. WHO About Cardiovascular Diseases. [(accessed on 30 October 2019)]; Available online: https://www.who.int/cardiovascular_diseases/about_cvd/en/
    1. Li M., Duan L., Li Y., Liu B. Long noncoding RNA/circular noncoding RNA–miRNA–mRNA axes in cardiovascular diseases. Life Sci. 2019;233:116440. doi: 10.1016/j.lfs.2019.04.066. - DOI - PubMed
    1. Hansen T.B., Jensen T.I., Clausen B.H., Bramsen J.B., Finsen B., Damgaard C.K., Kjems J. Natural RNA circles function as efficient microRNA sponges. Nature. 2013;495:384–388. doi: 10.1038/nature11993. - DOI - PubMed
    1. Honda T., Hirakawa Y., Nangaku M. The role of oxidative stress and hypoxia in renal disease. Kidney Res. Clin. Pract. 2019;38:414. doi: 10.23876/j.krcp.19.063. - DOI - PMC - PubMed

MeSH terms