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Comment
. 2020 Feb;41(2):93-94.
doi: 10.1016/j.it.2019.12.009. Epub 2020 Jan 13.

ACLY-matizing Macrophages to Histone Modification during Immunometabolic Reprogramming

Niamh C Williams  1 , Luke A O'Neill  2
Affiliations
Comment

ACLY-matizing Macrophages to Histone Modification during Immunometabolic Reprogramming

Niamh C Williams et al. Trends Immunol. 2020 Feb.

Abstract

Metabolic reprogramming in macrophages supports effector functions and differs depending on the activating stimulus. Lauterbach et al. now show that early metabolic alterations in macrophages driven by LPS signaling serve to increase the acetyl-CoA pool via citrate metabolism by the ATP-citrate lyase (ACLY), leading to histone acetylation and regulation of TLR-driven gene expression.

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