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. 2020 Oct;20(5):621-628.
doi: 10.1038/s41397-019-0140-y. Epub 2020 Jan 17.

Pharmacogenomic associations of adverse drug reactions in asthma: systematic review and research prioritisation

Charlotte King #  1 , Amanda McKenna #  1 , Niloufar Farzan  2 , Susanne J Vijverberg  2 , Marc P van der Schee  2 , Anke H Maitland-van der Zee  2 , Lambang Arianto  3 , Hans Bisgaard  3 , Klaus BØnnelykke  3 , Vojko Berce  4   5 , Uros PotoČnik  5 , Katja Repnik  5 , Bruce Carleton  6 , Denise Daley  6 , Fook Tim Chew  7   8 , Wen Chin Chiang  7   8 , Yang Yie Sio  7   8 , Michelle M Cloutier  9 , Herman T Den Dekker  10 , Liesbeth Duijts  10 , Johan C de Jongste  11 , F Nicole Dijk  11   12 , Carlos Flores  13   14   15 , Natalia Hernandez-Pacheco  13   16 , Somnath Mukhopadhyay  17 , Kaninika Basu  17 , Kelan G Tantisira  18   19 , Katia M Verhamme  20 , Juan C Celedón  21 , Erick Forno  21 , Glorisa Canino  22 , Ben Francis  23 , Munir Pirmohamed  24 , Ian Sinha #  25 , Daniel B Hawcutt #  26   27
Affiliations

Pharmacogenomic associations of adverse drug reactions in asthma: systematic review and research prioritisation

Charlotte King et al. Pharmacogenomics J. 2020 Oct.

Erratum in

  • Correction: Pharmacogenomic associations of adverse drug reactions in asthma: systematic review and research prioritization.
    King C, McKenna A, Farzan N, Vijverberg SJ, van der Schee MP, Maitland-van der Zee AH, Arianto L, Bisgaard H, BØnnelykke K, Berce V, PotoČnik U, Repnik K, Carleton B, Daley D, Chew FT, Chiang WC, Sio YY, Cloutier MM, Den Dekker HT, Duijts L, de Jongste JC, Dijk FN, Flores C, Hernandez-Pacheco N, Mukhopadhyay S, Basu K, Tantisira KG, Verhamme KM, Celedón JC, Forno E, Canino G, Francis B, Pirmohamed M, Sinha I, Hawcutt DB. King C, et al. Pharmacogenomics J. 2020 Oct;20(5):746. doi: 10.1038/s41397-020-0178-x. Pharmacogenomics J. 2020. PMID: 32704026 Free PMC article.

Abstract

A systematic review of pharmacogenomic studies capturing adverse drug reactions (ADRs) related to asthma medications was undertaken, and a survey of Pharmacogenomics in Childhood Asthma (PiCA) consortia members was conducted. Studies were eligible if genetic polymorphisms were compared with suspected ADR(s) in a patient with asthma, as either a primary or secondary outcome. Five studies met the inclusion criteria. The ADRs and polymorphisms identified were change in lung function tests (rs1042713), adrenal suppression (rs591118), and decreased bone mineral density (rs6461639) and accretion (rs9896933, rs2074439). Two of these polymorphisms were replicated within the paper, but none had external replication. Priorities from PiCA consortia members (representing 15 institution in eight countries) for future studies were tachycardia (SABA/LABA), adrenal suppression/crisis and growth suppression (corticosteroids), sleep/behaviour disturbances (leukotriene receptor antagonists), and nausea and vomiting (theophylline). Future pharmacogenomic studies in asthma should collect relevant ADR data as well as markers of efficacy.

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Conflict of interest statement

The authors declare that they have no conflict of interest.

Figures

Fig. 1
Fig. 1
Prisma flowchart showing screening and inclusion of studies.
See this image and copyright information in PMC

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