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. 2019 May 9;11(1):19-26.
doi: 10.1007/s13340-019-00395-9. eCollection 2020 Jan.

The correlation between blood oxidative stress and sialic acid content in diabetic patients with nephropathy, hypertension, and hyperlipidemia

Sedigheh Shahvali  1   2 , Armita Shahesmaeili  3 , Mojgan Sanjari  1 , Somayyeh Karami-Mohajeri  2
Affiliations

The correlation between blood oxidative stress and sialic acid content in diabetic patients with nephropathy, hypertension, and hyperlipidemia

Sedigheh Shahvali et al. Diabetol Int. .

Abstract

This clinical study was designed to find out the correlation between oxidative stress and sialic acid (SA) content of plasma and RBCs in patients with type 2 diabetes. We evaluated SA concentration and oxidative stress biomarkers in healthy subjects and diabetic patients with and without complications in a cross-sectional survey. Significant changes in oxidative stress biomarkers and RBC-SA were revealed in the diabetic patients compared to those in the healthy group. Plasma SA significantly increased with an increase in lipid peroxidation of RBCs (LPO-RBC) (P < 0.001) in the diabetic patients without complication. RBC-SA significantly decreased with an elevation in LPO-RBC (P < 0.001) in all the diabetic patients and those with nephropathy. There was no significant correlation between plasma and RBC-SA and other oxidative stress biomarkers in the diabetic subjects. In multiple logistic regression analysis, RBC-SA was independently related to LPO-RBC in all the diabetic patients and those with nephropathy. We conclude that the induction of LPO-RBC in diabetic patients and those with nephropathy may influence the SA decomposition of RBC membrane, thereby altering its functions and transporter activities. Therefore, LPO-RBC and SA levels in RBCs can be used for prediction of diabetic nephropathy, and further studies to evaluate other factors contributing to desialylation of RBC membrane are justified.

Keywords: Diabetes mellitus; Diabetic complications; Oxidative stress; Sialic acid; Type 2 diabetes.

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Conflict of interest statement

Conflict of interestThe authors declare that there is no conflict of interest associated with this manuscript.

Figures

Fig. 1
Fig. 1
Receiver-operating characteristic curve (ROC) of sensitivity plotted against 1-specificity of various biomarkers including RBC-sialic acid (RBC-SA) and plasma sialic acid (PSA), glutathione, superoxide dismutase (SOD), and lipid peroxidation (LPO) in a diabetic subjects, b diabetic patients with hyperlipidemia, c diabetic patients with hypertension, d diabetic patient with nephropathy
See this image and copyright information in PMC

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